非侵入性黄斑色素密度测量新方法的评价研究被引量：2

Evaluation on the noninvasive measurement of macular pigment optical density by a novel technique

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摘要目的以传统的异色闪烁光密度计（HFP）为参照,评价一种新型黄斑色素密度测量仪MPS1000测量黄斑色素密度（MPOD）的一致性和重复性.方法方法对比研究.分别采用MPS1000和传统HFP两种仪器测量59例（111只眼）健康受检者黄斑偏心率0.5°注视区的MPOD,并对其中8名受试者在1周后进行重复性测量.两种仪器测量得到的MPOD比较采用配对t检验.结果 MPS1000和传统HFP测量MPOD的平均值分别为0.47±0.15和0.40±0.18,配对t检验显示两种仪器测量值的差异具有统计学意义（t=3.95,P＜0.001）.两种仪器在0.5°注视区的MPOD测量值呈线性正相关（r=0.4,P＜0.001）.Bland-Altman分析显示两种仪器测量值的95％一致性界限为0.07±0.35.MPS1000与传统HFP测量MPOD的重复性系数分别为0.18和0.26.结论新型MPS1000对MPOD的测量结果重复性较好,比传统HFP的测量结果相对偏高,提示两种方法测量的MPOD值不宜做直接的对比分析. Objective To evaluate the measurement of macular pigment optical density （MPOD） by a novel instrument MPS1000 as compared to that measured by the traditional heterochromatic flicker photometer （HFP）.Methods Method-comparative study.MPOD at 0.5° eccentricity was measured simultaneously by the two different instruments in 111 eyes of the 59 healthy subjects.Test-retest variability was evaluated for each instrument over a 1-week period in 8 subjects.Result The mean MPOD levels measured by the MPS 1000 and HFP were 0.40 ± 0.18 and 0.47 ±0.15, respectively, which were statistically significantly different by the paired t-test （t=3.95, P〈0.001）.A positive linear correlation was observed for MPOD at 0.5° eccentricity between the two different instruments （r=0.4, P〈0.001）.The 95% limit of agreement was 0.07±0.35 as shown by Bland-Altman analysis.Inter-sessional repeatability, expressed as a coefficient of repeatability, was 0.26 for HFP and 0.18 for MPS1000.Conclusion MPOD levels measured by MPS1000 were significantly higher as compared to that measured by the traditional HFP, suggesting that it is inappropriate to directly compare the MPOD levels measured by these two methodologies.

作者韩旭任学焘李雪张军燕于洁刘宁朴

机构地区首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室

出处《中华眼科杂志》 CAS CSCD 北大核心 2015年第11期826-830,共5页 Chinese Journal of Ophthalmology

基金北京市教育委员会科技计划重点项目（KZ201110025028）国家自然科学基金（81070734）北京市卫生系统高层次卫生技术人才培养计划（2009208）

关键词黄斑色素光密度测定法诊断技术眼科结果可重复性 Macular pigment Densitometry Diagnostic techniques,ophthalmological Reproducibility of results

分类号 R774.5 [医药卫生—眼科]

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