摘要
以3-吡啶甲酸为原料,经酰氯化反应制成3-吡啶甲酰氯;再以亮氨酸为原料,经酰氯化后与乙醇反应生成相应的亮氨酸乙酯盐酸盐。在室温条件下,以三乙胺为缚酸剂,3-吡啶甲酰氯与亮氨酸乙酯盐酸盐经过酰化反应生成目标产物N-(3-甲酰吡啶)-亮氨酸乙酯。该化合物的结构通过1H NMR、13C NMR、IR和HRMS技术进行表征,并对其进行热裂解行为研究,分析鉴定出了39种裂解产物,多数为致香物质。对目标物进行卷烟加香评吸,结果表明该物质能改善卷烟吸味,减轻卷烟吸食刺激性,增强香气。
Using 3-pyridine carboxylic acid as raw material, 3-pyridine carbonyl chloride was obtained by acylation reaction. The leucine ethyl ester hydrochloride was synthesiszed from leucine and ethanol by acylation reaction. At room temperature, N-（3-formyl pyridine） leucine ethyl ester was prepared with 3-pyridine carbonyl chloride and leucine ethyl ester hydrochloride as raw materials, triethylamine as absorb acid agent. The structure of target product was confirmed by 1^H NMR, 13^C NMR, IR and HRMS spectra. The applications of this ester in cigarette flavoring were studied as well. Thirty-nine kinds of pyrolysis products were identified, they were almost aroma components. The sensory evaluation showed that the new compound could improve the cigarette taste and flavor, reduce smoking irritation.
出处
《香料香精化妆品》
CAS
2015年第5期28-32,44,共6页
Flavour Fragrance Cosmetics
基金
河南省科技厅重点科技攻关项目"新型吡嗪类香味化合物的合成及其应用研究"(编号132102210042)
关键词
吡啶
亮氨酸
合成
热裂解
卷烟加香
pyridine leucine synthesis pyrolysis tobacco flavoring
