摘要
目的分析老年人脂肪肝患者采用硫普罗宁治疗的临床效果。方法随机选取2013年3月—2015年3月在该院消化内科就诊的60例老年脂肪肝患者按照双盲法随机分为研究组(在一般常规治疗的同时采用硫普罗宁注射治疗)和对照组(单独采用一般常规治疗),将两组患者临床治疗效果以及治疗前后肝功能指标、血脂指标变化情况进行对比分析。结果研究组患者治疗总有效率为96.7%,其中显效21例,有效8例,无效1例;对照组治疗总有效率为83.3%,其中显效20例,有效5例,无效5例,研究组患者治疗有效性显著高于对照组(P<0.05)。研究组患者治疗后谷丙转氨酶、甘油三酯以及碱性磷酸酶水平均明显低于治疗前(P<0.05),且显著低于对照组(P<0.05),两组患者的总胆红素、高密度脂蛋白、低密度脂蛋白、胆固醇等相关指标水平并没有显著改变(P>0.05)。结论老年人脂肪肝患者应用硫普罗宁治疗的临床疗效显著,可有效改善患者的临床症状及体征,也可降低血脂及谷丙转氨酶等相关指标,且对患者的不良反应较轻,值得在临床上进一步推广、应用。
Objective To observe the effect of tiopronin in the treatment of fatty liver in elderly. Methods 60 elderly patients with fatty liver treated in the Department of Gastroenterology of our hospital form March 2013 to March 2015 were, according to the double-blind method, randomly divided into research group（ with conventional treatment and the injection of tiopronin and control group（with single use of conventional treatment）. The clinical treatment effects of the patients in the two groups, and changes of liv-er function index, blood lipid indexes before and after treatment of the two groups were comparatively analyzed. Results The total effective rate of the patients in the research group was 95%, in which 21 cases were markedly improved, 8 cases demonstrated ef-fective and 1 case was ineffective; while the total effective rate of the patients in the control group was 83.3%, in which 20 cases were markedly improved, 5 cases demonstrated effective and 5 cases were ineffective, and the total effective rate of the research group was obviously higher than that of the control group （P〈0.05）.The levels of alt, triglycerides, and alkaline phosphatase of the patients in the research group after treatment were obviously lower than that before treatment（P〈0.05）, as well as that of the control group after treatment（P〈0.05）.There were no obviously changes in the levels of total bilirubin, high density lipoprotein cholesterol （hdl-c）, low density lipoprotein, cholesterol of both the two groups （P〉0.05）. Conclusion The effect of tiopronin in the treat-ment of fatty liver in elderly is remarkable, which can effectively improve the clinical symptoms and sign, reduce the levels of blood fat and Alt, and which, with less adverse reactions, is worthy of further promotion and application in clinic.
出处
《中外医疗》
2015年第19期130-131,共2页
China & Foreign Medical Treatment
关键词
老年人
硫普罗宁
脂肪肝
疗效观察
The aged
Tiopronin
Fatty liver
Observation on the clinical effect
