摘要
目的探讨参附注射液联合卡维地洛治疗慢性心力衰竭的临床疗效。方法选择2012年9月—2014年6月莱芜中心医院收治的慢性心力衰竭患者96例,按照随机数字表法分为观察组和对照组,各48例。观察组患者给予参附注射液联合卡维地洛治疗,对照组患者给予卡维地洛治疗,均治疗3个月。比较两组患者治疗前后心功能指标〔心率、左心室射血分数(LVEF)、每搏输出量、心输出量〕、血压〔收缩压(SBP)和舒张压(DBP)〕及动脉血气分析指标〔p H值、氧分压(Pa O2)、二氧化碳分压(Pa CO2)〕,观察两组患者治疗期间不良反应情况。结果治疗前两组患者心率、LVEF、每搏输出量及心输出量比较,差异无统计学意义(P>0.05);治疗后观察组患者心率低于对照组,LVEF、每搏输出量及心输出量高于对照组(P<0.05)。治疗前两组患者SBP和DBP比较,差异无统计学意义(P>0.05);治疗后观察组患者SBP和DBP均低于对照组(P<0.05)。治疗前两组患者p H值、Pa O2及Pa CO2比较,差异无统计学意义(P>0.05);治疗后两组患者p H值比较,差异无统计学意义(P>0.05);治疗后观察组患者Pa O2高于对照组,Pa CO2低于对照组(P<0.05)。治疗期间对照组患者不良反应发生率为8.3%,观察组为6.2%,差异无统计学意义(P>0.05)。结论参附注射液联合卡维地洛治疗慢性心力衰竭的临床疗效确切,其能有效改善患者心功能、降低外周血管阻力、改善组织缺血缺氧状态,且安全性较高。
Objective To investigate the clinical effect of shenfu injection combined with carvedilo on chronic heart failure.Methods A total of 96 patients with chronic heart failure were selected in Laiwu Centeral Hospital from September 2012 to June 2014,and they were divided into control group and observation group according to random number table,each of 48 cases.Patients of control group were only given carvedilo,while patients of observation group were given shenfu injection combined with carvedilo,both groups treated for 3 months.Cardiac function index（including HR,LVEF,SV and CO）,blood pressure（including SBP and DBP）and arterial blood-gas analysis index（including p H,Pa O2 and Pa CO2）before and after treatment were compared between the two groups,and incidence of adverse reactions during treatment was observed.Results No statistically significant differences of HR,LVEF,SV or CO was found between the two groups before treatment（P〉0.05）;after treatment,HR of observation group was statistically significantly lower than that of control group,while LVEF,SV and CO of observation group were statistically significantly higher than those of control group（P〈0.05）.No statistically significant differences of SBP or DBP was found between the two groups before treatment（P〉0.05）; while SBP and DBP of observation group were statistically significantly lower than those of control group after treatment（P〈0.05）.No statistically significant differences of p H,Pa O2 or Pa CO2 was found between the two groups before treatment,nor was p H between the two groups after treatment（P〉0.05）,while Pa O2 of observation group was statistically significantly higher than that of control group,Pa CO2 of observation group was statistically significantly lower than that of control group（P〈0.05）.The incidence of adverse reactions of control group was 8.3% during treatment,that of observation group was 6.2%,the difference was not statistically significantly different（P〉0.05）.Conclusion Shenfu injection combined with carvedilo has certain clinical effect of in treating chronic heart failure,can effectively improve the cardiac function,reduce peripheral vascular resistance,relieve the Ischemic and anoxic conditions,and is safe.
出处
《实用心脑肺血管病杂志》
2015年第10期118-120,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心力衰竭
参附注射液
卡维地洛
治疗结果
Cardiac failure
Shenfu injection
Carvedilo
Treatment outcome
