摘要
目的观察香丹注射液联合参附液在治疗长期脾胃虚寒型老年女性患者中冬季继发胸痹前、后生理指标的变化,为临床治疗提供实验室依据。方法选择2010—2013年冬季收治的84例脾胃虚寒型胸痹老年女性,随机分成对照组、治疗组各42例,对照组予静滴香丹注射液,胃腹胀者口服多潘立酮,消化和食欲不良者予多酶片,便溏腹泻者予以思密达,治疗组予以香丹注射液联合参附注射液静滴,2组疗程均为2周。治疗前后,检测凝血酶原时间(prothrombin,PT)、部分活化凝血酶原时间(activated partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,FIB)、D-二聚体(D-dimer,DD)、一氧化氮(nitric oxide,NO)、内皮素(endothelin,ET)、缺血修饰白蛋白(ischemia modified albumin,IMA)、血压(blood pressure,BP)指标并进行比较。结果 1治疗前:2组观察指标差异无统计学意义(P>0.05);2治疗前后:对照组PT、APTT、FIB、DD、ET、IMA指标差异有统计学意义(P<0.05或P<0.01);治疗组PT、APTT、FIB、DD、ET、IMA、BP指标差异有统计学意义(P<0.05或P<0.01);治疗后2组BP差异有统计学意义(P<0.01),其他指标差异无统计学意义(P>0.05)。结论香丹注射液联合参附注射液可改善冬季虚寒型胸痹老年女性患者的血液凝固性、血管内皮功能和血压指标。
Objective To observe the efficacy of combined Xiang Dan and Shen Fu injection on improving the physiological indexes in elderly women with deficiency-cold of spleen-stomach for a long timesecondarychest impedimentin winterand provide experimental reference for the clinical treatment. Methods Eighty-fourelderly women with chest impediment of type belong to weakness of spleen and stomach from 2010 to 2013 were randomly divided into therapy group（ 42 cases）and control group（ 42 cases）. The control group was administered with Xiang Dan injection and other symptomatic treatment,while the therapy groupreceived Xiang Dan and Shen Fu injection,the course was two weeks. PT,APTT,FIB,DD,NO,ET,IMA and BP were tested and compared before and after the treatment. Results ① Before the treatment,there were no significant differencesin the indexes between thetwo groups（ P〉0. 05）. ②PT,APTT,FIB,DD,NO,ET and IMA in the control group were improved obviouslyafter the treatment（ P〈0. 05 or P〈0. 01）; PT,APTT,FIB,DD,NO,ET,IMA,and BP in the therapy groupwere improved significantlyafter the treatment（ P〈0. 05 or P〈0. 01）; ③There was significant difference in BP between the two groups（ P〈0. 01）. Conclusion The blood vesselendothelial function,blood coagulability,bloodpressureand other indexes in the elderly women with deficiency-cold of spleen-stomach for a long timesecondarychest impediment can be improved by using Xiang Dan and Shen Fu injection.
出处
《中华全科医学》
2015年第12期2036-2037,2056,共3页
Chinese Journal of General Practice
关键词
香丹
参附
"寒证
胸痹
生理指标
Xiang Dan
Shen Fu
Asthenia-cold syndrome
Chest impediment
Physiological indexes
