摘要
目的观察戊酸雌二醇配伍米非司酮、米索前列醇在稽留流产中的临床疗效。方法将稽留流产患者84例随机分为治疗组和对照组各42例。治疗组患者先口服戊酸雌二醇5mg,每天3次,连服3d,第4天顿服米非司酮150mg,第6天服米索前列醇600μg。对照组患者空腹口服米非司酮50mg,每12小时1次,连续给药3d,第4天空腹口服米索前列醇600μg。观察2组患者口服米索前列醇后6h内胚胎娩出情况及出血量,服用米索前列醇6h后清宫,清宫后3d复查彩色多普勒超声检查有无残留。比较2组患者一次清宫和二次清宫情况。结果治疗组胚胎娩出比例明显高于对照组,娩出时间短于对照组,出血量少于对照组,一次清宫率高于对照组,二次清宫率低于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论戊酸雌二醇配伍米非司酮、米索前列醇可明显提高胚胎娩出率,提高一次清宫率,而且可明显降低出血量,疗效显著,值得临床推广应用。
Objective To investigate the clinical efficacy of estradiol valerate combination with mifepristone,misoprostol in missed abortion. Methods 84 patients of missed abortion were randomly divided into treatment group and control group,each of 42 cases. Treatment group patients first oral estradiol valerate 5mg,3 times a day,and even clothes 3d,4th day dayton mifepristone 150 mg,the six days oral misoprostol 600μg. Control group patients fasting oral mifepristone 50 mg,once every 12 hours,continuous administration of 3d,the four days of fasting oral misoprostol 600μg. Within 6h after oral misoprostol observed the embryo expulsion cases and bleeding volume of two groups. 6h after taking misoprostol arranged curettage. 3d after curettage,Reviewed color doppler ultrasound to check for residues. Compared the once and second curettage of two groups. Results The delivered proportion of treatment group was significantly higher than control group,delivery time was shorter than control group,bleeding was less than control group,once curettage rate was higher than control group,second curettage rate was lower than control group,the differences were statistically significant（ P〈0. 05 or P〈0. 01）. Conclusion The treatment of estradiol valerate combined with mifepristone,misoprostol can significantly improve embryo expulsion rate and increase the rate of a curettage,and can significantly reduce the amount of bleeding,has a significant effect,worthy of clinical application.
出处
《临床合理用药杂志》
2015年第34期27-28,共2页
Chinese Journal of Clinical Rational Drug Use
