摘要
目的了解2型糖尿病肾衰竭患者血液透析HCV感染流行病学特征及危险因素分析,为科学预防透析患者感染HCV提供科学依据。方法收集2004-2014年宁夏人民医院透析中心进行透析的2型糖尿病肾衰竭患者流行病学资料,纳入研究1 926例;酶联免疫吸附试验ELISA检测患者静脉血HCV抗体,Logistic回归分析HCV感染危险因素。结果透析期间HCV感染率为21.13%(407/1 926);2004-2014年感染率呈现下降趋势(χ2趋势=29.26,P=0.001<0.05);2004年透析患者HCV感染率为20.31%,2005年采用肝炎病例与非肝炎病例分区透析后HCV感染率降为10.19%,2008年使用一次性透析器后HCV感染率降为6.35%。回归分析显示,HCV感染的危险因素为血液透析持续时间、透析设备破膜、行透析治疗医院数和输血次数。结论透析机交叉感染和输血是2型糖尿病肾衰竭患者感染丙肝病毒的危险因素,血透室应加强对透析机消毒的管理;对贫血患者使用促红细胞生成素。
Objective To determine the epidemiology of hepatitis C virus （HCV） infection in patients with type 2 diabe- tes mellitus and renal failure in order to provide a scientific basis for preventing that infection in patients on dialysis. Methods Epidemiological data on patients with type 2 diabetes and renal failure were collected from the People＇s Hospital of Ningxia from 2004--2014, and 1 926 patients served as subjects. Venous blood was tested for anti-HCV antibodies u- sing an enzyme-linked immunosorbent assay （ELISA）. The risk factors for HCV infection were analyzed using logistic re- gression analysis. Results The rate of infection with HCV was 21. 13% during dialysis. The rate of infection with HCV tended to decline （x^2 -29.26, P=0. 001〈0.05） from 2004--2014. The rate of infection with HCV was 20.31% in 2004. Patients were differentiated into those with hepatitis and those without hepatitis in 2005. After dialysis, the rate of infection with HCV was 10.19}6. Use of disposable dialyzers began in 2008, and the rate of infection with HCV was 6.35%. Regression analysis indicated that the risk factors for infection with HCV were the duration of hemodialysis, a dialyzer with a broken membrane, the rounds of hemodialysis, and the number of blood transfusions. Conclusion Cross-infection via a dialysis machine and blood transfusions are risk factors for HCV infection in patients with type 2 dia- betes mellitus and renal failure. The sterile management of dialysis machines in the dialysis unit should be enhanced and patients with anemia should be given the hormone erythropoietin.
出处
《中国病原生物学杂志》
CSCD
北大核心
2015年第11期1044-1046,共3页
Journal of Pathogen Biology
关键词
2型糖尿病肾衰竭患者
透析
丙肝病毒
感染
Patients with type 2 diabetes and renal failure
dialysis
hepatitis C virus
infection
