摘要
目的研究阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的视网膜神经纤维层厚度(retinal nerve fiber layer,RNFL)。方法连续选取主诉睡眠呼吸暂停的患者以及健康体检者进行多导睡眠检测和详细的眼科检查,最终Apnea-Hypopnea指数≥5的43例OSAHS患者纳入OSAHS组,Apnea-Hypopnea指数<5的36例健康体检者纳入对照组,两组患者年龄、性别、身体质量指数差异均无统计学意义。对所有受试者进行血氧饱和度和眼压测量,并使用Stratus OCT 3000检测受试者上方、下方、鼻侧、颞侧和平均视网膜神经纤维层厚度。对所有受试者规律随访12个月。结果OSAHS组和对照组平均血氧饱和度分别为89.87%±3.69%和96.11%±1.51%,差异有统计学意义(t=2.43,P=0.04);初诊和12个月时,两组患者之间眼压差异均无统计学意义(t=7.32,P=1.37;t=5.94,P=0.86);OSAHS组平均RNFL厚度初诊测量值为103.47±6.93μm,12个月时降至96.82±8.14μm,在随访期内出现渐进性下降;对照组初诊和12个月的平均RNFL测量值差异无统计学意义;12个月时,OSAHS组上方、下方和鼻侧RNFL厚度较对照组有所降低;平均RNFL厚度减少的绝对值与AHI呈正相关。结论部分OSAHS患者视网膜神经纤维层厚度有所降低,且降低程度与OSAHS严重程度相关。
Objective To observe the retinal nerve fiber layer （RNFL） thickness in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods Healthy people and patients complained of sleep apnea were continuously selected, received polysom- nography and detailed eye examination. Forty three patients with OSAHS whose Apnea - Hypopnea index 35 and 36 healthy people whose Apnea -Hypopnea index 〈 5 were enrolled in this prospective study. There were no significant differences between the two groups of pa- tients with age, sex, body mass index. The oxygen saturation and intraocular pressure were examined, and Stratus OCT 3000 was used to examine the RNFL thickness. The follow up time was 12 months. Results The average oxygen saturation in OSAHS group and the control group were 89.87% ± 3.69% and 96.11% ± 1.51% , and the difference was statistically significant （t = 2.43, P = 0. 04）. At the first visit and the 12th month, there was no significant change in IOP between OSAHS group and the control group （ t = 7.32, P = 1.37 ; t = 5.94, P =0.86）. The average RNFL thickness at the first visit was 103.47 ±6.93μm, and decreased progressively to 96.82 ±8.14μ m at the 12th month. In the control group, the average RNFL thickness didn＇t differ in 0th and 12th month. In the 12th month, statistically significance of superior, inferior and nasal RNFL thickness were found between OSAHS patients and controls at the 12th month. There was a positive correlation between apnea -hypopnea index and RNFL thickness reduction. Conclusion RNFL thickness decreased in some OSAHS patients, and the decrease was associated with the severity of OSAHS.
出处
《医学研究杂志》
2015年第11期98-100,共3页
Journal of Medical Research
