HCG和GnRH-a在微刺激方案IVF中扳机作用效果分析被引量：4

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摘要目的回顾性分析在卵巢储备功能低下患者微刺激方案IVF中,绒毛膜促性腺激素（HCG）及促性腺激素释放激素激动剂（GnRH-a）扳机的应用效果。方法选择80例应用来曲唑联合HMG促排卵方案行IVF的卵巢储备功能低下患者,根据应用扳机剂的不同,分为HCG扳机组45例和曲普瑞林扳机组35例,当主导卵泡平均直径达18 mm时,HCG组肌内注射HCG 6 000-10 000 U。曲普瑞林扳机组皮下注射醋酸曲普瑞林0.1 mg。比较2组患者年龄、不孕年限、体重指数、基础FSH、Gn天数、Gn用量、扳机日E2、未获卵周期率、获卵数、成熟卵率、受精率、可移植胚胎率、优胚率、取消移植率、临床妊娠率。结果 2组患者年龄、不孕年限、体重指数、基础FSH值、Gn天数、Gn用量、扳机日E2水平、获卵数、成熟卵率、受精率、可移植胚胎率、优胚率、取消移植率、临床妊娠率比较,差异无统计学意义（P〉0.05）。结论 GnRH-a可以替代HCG作为扳机剂应用于微刺激方案行IVF的卵巢储备功能低下患者。

作者刘宝莲宁艳春樊桂玲韩宝生于春玲张惠娟曾彬金晔

机构地区河北省唐山市妇幼保健院生殖遗传科

出处《河北医药》 CAS 2015年第23期3619-3620,共2页 Hebei Medical Journal

关键词促性腺激素释放激素激动剂绒毛膜促性腺激素卵巢储备功能低下

分类号 R711.75 [医药卫生—妇产科学]

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1Reveli A, Casano S, Salvagno F, et al. Milder is better Advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertiliza- tion. Reprod Biol Endocrinol,2011,9 :25.
2Shalaar K, Jehoshua D. Prevention of OHSS: GnRH agonist versus I4CG to trigger ovulation. Reproductive Bio Medicine Online,2009,19:59-60.
3Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of poor response to ovarian stimulation for in vitro fertilization : the Bologna criteria. Hum Reprod,2011,26 : 1616-1624.
4唐洁,许波,江小华,陈大蔚,侯贺礼,史庆华.卵母细胞发育停滞[J].生殖医学杂志,2009,18(3):211-214. 被引量：5
5林秀峰,杜静,吴日然,张旭宾,柯玩娜,吴嘉齐,谭爱玲.促排卵治疗与残留卵泡[J].生殖医学杂志,2009,18(A01):39-42. 被引量：2
6杨隽,王树玉,马延敏,贾蝉维,李颖.短效GnRH-a在促排卵周期中诱导卵泡成熟与排卵的研究[J].中国优生与遗传杂志,2008,16(9):102-105. 被引量：3
7江成龙,郑蓉,黄晓卉,张颖,胡冬玲,罗丽娟,张昌军.来曲唑/FSH促排卵中GnRHa与hCG诱发卵泡成熟效果的比较[J].生殖与避孕,2011,31(1):62-66. 被引量：12
8Youssef MA, Van der Veen F, Al-Inany HG, et al. Gonadotropin releasing hormone agonist versus HCG for oocyte triggering in antagonist assisted reproductive technology cycles. Cochrane Database Syst Rev,2011,32: 8046.
9Humaidan P,Bredkjaer HE,Westergaard L, et al. 1500 IU human chori- onic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropinreleasing hormone agonist is used for ovulation induc- tion : a prospective, randomized, controlled study. Fertil Steril,2010,93 : 847 -854.

二级参考文献47

1张韶珍,夏英英.诱导排卵与卵巢囊肿[J].中国优生与遗传杂志,2006,14(1):103-104. 被引量：2
2Racki WJ, Richter JD. CPEB controls oocyte growth and follicle development in the mouse[J]. Development, 2006, 133(22) : 4527-4537.
3Dekel N. Cellular, biochemical and molecular mechanisms regulating oocyte maturation [J]. Mol Cell Endocrinol, 2005,234(1-2) : 19-25.
4Peters JM. The anaphase promoting complex/cyclosome: amachine designed to destroy [J]. Nat Rev Mol Cell Biol, 2006,7(9) :644-656,
5Marangos P,Verschuren EW, Chen R, et al. Prophase Ⅰ arrest and progression to metaphase Ⅰ in mouse oocytes are controlled by Emil-dependent regulation of APC(Cdhl) [J]. J Cell Biol,2007,176(1) :65-75.
6Jones KT. Meiosis in ooeytes: predisposition to aneuploidy and its increased incidence with age [J]. Hum Reprod Update,2008,14(2) : 143-158.
7Grφndahl C. Oocyte maturation. Basic and clinical aspects of in vitro maturation (IVM) with special emphasis of the role of FF-MAS [J]. Dan Med Bull,2008,55(1) :1-16.
8Rauh NR,Sehmidt A,Bormann J,et al, Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErpl for degradation [J]. Nature, 2005,437(7061) : 1048-1052.
9Hartshorne G,Montgomery S,Klentzeris L. A case of failed oocyte maturation in vivo and in vitro[J]. Fertil Steril, 1999,71(3) :567-570.
10Levran D,Farhi J,Nahum H,et al. Maturation arrest of human oocytes as a cause of infertility: case report [J], Hum Reprod,2002,17(6):1604-1609.