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类黄酮化合物作为胆碱酯酶抑制剂的研究进展

Research Progress on Flavonoids as Cholinesterase Inhibitors
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摘要 类黄酮是一类广泛分布于自然界的天然化合物,具有抗肿瘤、抗氧化、抗炎、血管舒张、神经元保护、保肝等多种生理活性,尤其是具有低毒的优势,使其在预防和治疗慢性疾病方面,如阿尔茨海默症(Alzheimer's disease,AD)引起人们广泛关注。然而,类黄酮化合物与胆碱酯酶作用的研究报道还不是很多,因此,本文总结了近几年类黄酮化合物作为胆碱酯酶抑制剂的研究进展,期望为今后开发抗AD药物提供参考。 Flavonoids are a large class of compounds widely distributed in nature. Many of them expressed a wide range of biological activities such as anti-tumor, antioxidant, anti-inflammatory, vasodilator, neuron protection, hepatoprotective, and so on, espcially they show so low toxicity that they could be potential to treatment for chronic disease, such as Alzheimer’s disease ( AD) . In recent years, many research groups choose flavonoids to develop new drug for treatment of AD. Herein, current researches in flavonoids as cholinesterase inhibitors were systematically summarized, which can serve as a reference for designing new anti-AD drugs.
出处 《广州化工》 CAS 2015年第22期24-26,35,共4页 GuangZhou Chemical Industry
关键词 类黄酮 阿尔茨海默症 胆碱酯酶 抑制剂 flavonoids Alzheimer’s disease cholinesterase inhibitor
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