摘要
目的 观察早期妊娠时甲状腺功能正常仅甲状腺自身抗体阳性与阴性孕妇妊娠合并症、并发症及妊娠结局的区别,了解甲状腺自身抗体对妊娠的影响.方法 选择妊娠早期523例甲状腺功能正常、甲状腺过氧化物酶抗体（TPO-Ab）或（和）甲状腺球蛋白抗体（TGAb）阳性孕妇为观察组,1046例甲状腺功能正常、甲状腺自身抗体阴性妊娠早期孕妇为对照组,随访妊娠结局.结果 观察组与对照组孕妇妊娠中晚期发生妊娠期糖尿病、妊娠期高血压疾病及亚临床甲状腺功能减退,临床甲状腺功能减退的比例差异有统计学意义（P＜0.05）,观察组与对照组孕妇流产、早产、胎膜早破、胎儿窘迫发生率比较差异有统计学意义（P＜0.05）,新生儿窒息率,低体重儿发生率差异无统计学意义（P＞0.05）.结论 妊娠早期甲状腺功能正常而甲状腺自身抗体阳性的孕妇妊娠中晚期发生妊娠期糖尿病、妊娠期高血压疾病及亚临床甲状腺功能减退,临床甲状腺功能减退的比例明显增多,不良妊娠结局事件增多,因此,应当重视妊娠早期甲状腺功能和甲状腺自身抗体筛查,并关注单纯性甲状腺自身抗体阳性的孕妇.
Objective To observe the effect of thyroid autoantibodies to the pregnancy complications and outcomes in early pregnancy women with normal thyroid function. To explore the effect of thyroid autoantibodies in pregnancy.Methods The study group were 523 cases of early pregnant women with normal thyroid function whose thyroid peroxidase antibody or （ and ） thyroglobulin antibody were positive.The control group were another 1046 cases of early pregnant women with normal thyroid function whose thyroid autoantibody were negative. Their pregnancy outcomes were followed. Results The Incidence of gestational diabetes, hypertensive disorders in pregnancy, subclinical hypothyroidism, clinical hypothyroidism during the second and third trimester of pregnancy was compared, and the difference in the two groups was significant （P〈0.05） . There were differences in the incidence of miscarriage, premature birth, premature rupture of membranes, fetal distress （ P〈0.05 ） .But there were no differences in the incidence of neonatal asphyxia, low birth weight children （ P〉0.05 ） .Conclusion The Incidence ofgestational diabetes, hypertensive disorders in pregnancy, subclinical hypothyroidism, clinical hypothyroidism during the second and third trimester of pregnancy were higher in early pregnant women with normal thyroid function whose thyroid autoantibody were positive.The incidence of adverse pregnancy outcomes was also higher.So we should pay attention to thyroid function and thyroid autoantibodies screening in early pregnancy and follow-up simple thyroid autoantibody-positive pregnant women.
出处
《浙江临床医学》
2015年第12期2091-2093,共3页
Zhejiang Clinical Medical Journal
