摘要
目的：比较多萘哌齐联用奥氮平与单独使用多萘哌齐治疗老年期痴呆认知功能的临床疗效。方法：共65例老年期痴呆患者随机分为联合使用组与单独使用组,针对两组病人,双盲对照治疗,治疗过程以8周为一个疗程,分别在治疗前、治疗第4周末、治疗第8周末用简易智能精神状态量表（MMSE）测评临床疗效,评估认知功能。结果：在治疗前联合使用组与单独使用组MMSE评分无显著差异。临床治疗第4周末与治疗前比较,联合使用组及单独使用组MMSE评分均无显著差异。疗程第8周末,单独使用组及联合使用组分别与治疗前比较MMSE评分均有显著差异（t=4.786～7.825;P〈0.05）。此外,联合使用组与单独使用组在治疗第4周末MMSE评分无明显差异,治疗第8周末有明显差异（t=2.59,P〈0.05）。结论：单独使用组与联合使用组对于改善老年痴呆的认知功能均有效,但多萘哌齐联用奥氮平能更好地改善老年痴呆患者的认知功能。
Objective：To compare the effect of combination therapy of Donepezil and Olanzapine and only Donepezil therapy in the treatment of cognitive function in senile dementia .Methods：A total of 65 senile dementia patients were randomly divided into two groups ,Donepezil group （ single group ） and Done-pezil combined with Olanzapine group （ combination group ） ,receiving treatment for 8 weeks.The Mini-mental State Examination（MMSE）,was used to assess before treatment ,and at 4 weekend and 8 week-end.Results：Before treatment,there was no significant difference in MMSE score in both two groups .In 4 weeks after treatment ,there was no significant difference in MMSE score in both two groups .At 8 week-end,the significant difference was found in both two groups （t=4.786～7.825,P〈0.05）.In addition,to compare the two groups ,in 4 weeks after treatment ,there was no significant difference in MMSE score ,At 8 weekend,the significant difference was found in MMSE between the two groups （t=2.59,P〈0.05）. Conclusion：Both groups can improve the cognitive function in senile dementia , but combination group can more effectively improve the cognitive function in senile dementia.
出处
《中国健康心理学杂志》
2015年第12期1768-1771,共4页
China Journal of Health Psychology
