摘要
应用流式细胞仪检测强直性脊柱炎(AS)及类风湿关节炎(RA)患者外周血淋巴细胞(PBL)表面IL-2受体(IL-2R)及经PHA刺激、体外培养产生的IL-2。结果表明,AS患者PBL表达IL-2R无明显增加,而RA患者则明显高于正常人及AS患者(P<0.01);AS及RA患者PBL体外培养产生IL-2明显多于正常人(P<0.01),提示IL-2异常在AS及RA患者免疫功能失调中起重要作用。
The production of IL-2 by peripheral blood lymphocytes from patients with Ankylosing Spondylitis (AS)and Rheumatoid Arthritis (RA) was compared with that of healthy controls. Patients with AS and RA showed a significant overproduction of IL-2.Membrane-bound IL-2 receptor was recognized by monoclonal anti-Tac antibody by using a flow cytometry. There was a marked increase of IL-2 receptor in patients with RA, while the level of IL-2 receptor in patients with AS was comparable to that of normal controls. The results suggested that there was obvious abnormalities of membrane-bound IL-2 receptor expressing and production of IL-2 in patients with AS and.RA which may contribute to the pathogenesis of these diseases.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1991年第3期172-174,共3页
Chinese Journal of Immunology
关键词
强直性脊柱炎
类风湿关节炎
IL-2
Ankylosing Spondylitis
Rheumatoid Arthritis
IL-2
IL-2 receptor
Flow Cytometry
