摘要
目的探讨慢性萎缩性胃炎与巨幼细胞贫血的相关性,为临床诊治提供参考。方法回顾分析自2012年10月—2014年10月期间该院收治的120例慢性萎缩性胃炎患者的临床资料。根据患者是否伴发巨幼细胞贫血,将其分为观察组(n=67)和对照组(n=53)。实验室检查患者叶酸(FA)和维生素B12的水平,胃镜检查时取胃黏膜组织作快速尿素酶试验检查幽门螺旋杆菌(Helicobacter pylori,Hp)。结果经胃镜+病理检查,发现观察组患者的维生素B12、叶酸水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组Hp感染率为67.16%,对照组Hp感染率为69.81%;Hp阳性患者的维生素B12水平及叶酸水平均显著低于Hp阴性患者,差异具有统计学意义(P<0.05)。结论 Hp阳性患者的血清维生素B12和叶酸水平显著低于Hp阴性患者,慢性萎缩性胃炎与巨幼细胞贫血有相关性,慢性萎缩性胃炎可诱发巨幼细胞贫血,巨幼细胞贫血能加剧慢性萎缩性胃炎的病情。
Objective To investigate the relationship between chronic atrophic gastritis and megaloblastic anemia as a reference for clinical staff. Retrospective analysis of 120 case of chronic atrophic gastritis in our hospital, which happened from October2012 to October 2012. Methods 120 cases of patients were divided into two groups,observation group and control group, depending on whether or not the patients suffering megaloblastic anemia. To determine the level of folic acid（FA） and the level vitamin B12 of all patients. To got tissue of gastric mucosa In the time of stomachoscopy, and then determined the status of Helicobacter pylori（Hp） by rapid urease test. Results The level of FA and Vitamin B12 of observation group patients were lower than control group patients, showing significant difference（P〈0.05）. Observation group＇s Hp infection rate was 67.16% and control groups ＇s Hp infection rate was 69.81%. Besides, the level of vitamin 12 of the positive Hp infected patients was lower than the Hp negative patients＇, showing significant difference（P〈0.05）. However, the level of FA have no difference between positive Hp infected patients and Hp negative patients. Conclusion Chronic atrophic gastritis is related with megaloblastic anemia. Chronic atrophic gastritis can induce megaloblastic anemia, and megaloblastic anemia can aggravate chronic atrophic gastritis. Hp is major risk factor.
出处
《中外医疗》
2015年第15期45-46,共2页
China & Foreign Medical Treatment
