摘要
目的研究不同方案治疗成人急性早幼粒细胞白血病(APL)的效果比较。方法根据治疗方式将该院86例成人急性早幼粒细胞白血病患者分为单药组(25例)、双药组(31例)、三药组(30例),在诱导缓解期、巩固维持期分别采取对应治疗方式,比较两组完全缓解(CR)率、复发率、3年生存率及不良反应发生率。结果单药、双药、三药组CR率分别为84.0%、87.1%、93.3%,呈递增趋势,比较差异无统计学意义(P>0.05),复发率24.0%、12.9%、10.0%递减,比较差异无统计学意义(P>0.05),3年生存率44.0%、71.0%、90.0%呈递增趋势,双药组与三药组显著高于单药组,对比差异有统计学意义(P<0.05);3组不良反应发生率比较差异无统计学意义(P>0.05)。结论 ATO+ATRO+蒽环类药物治疗成人急性早幼粒细胞白血病完全缓解率高,复发率低,3年生存率高,不良反应较轻微,具有较高的临床应用价值。
Objective To compare the effect of different therapy for adult patients with acute promyelocytic leukemia. Methods According to different therapy, 86 cases of adult patients with acute promyelocytic leukemia were divided into single drug group（25 cases）, double medicine group（31 cases）, three medicine group（30 cases）. Corresponding treatments were respectively performed during induction therapy and consolidation. Complete remission（CR） rate, recurrence rate, 3 year survival rate and the incidence of adverse reactions were compared between the two groups. Results Single, double, three medicines group CR rate of84.0%, 87.1% and 93.3%,respectively, showed a trend of increasing, no statistical significance（P〉0.05）, the recurrence rate of24.0%,12.9%,10.0%, is no statistical significance（P〉0.05）, 3 year survival rate was 44.0%, 71.0%, 90.0% showed a trend of increasing, double medicine group and the three drugs group is significantly higher than single drug groups, compared to significant difference（P〈0.05）; Three groups of incidence of adverse reactions compared with no statistical significance（P〉0.05）. Conclusion ATO ＋ ATRO ＋ anthracycline-based drugs treatment of adult acute myelocytic leukemia complete response rate is high, early recurrence rate is low, 3 year survival rate is high, the adverse reaction is mild, has high clinical value.
出处
《中外医疗》
2015年第15期58-59,共2页
China & Foreign Medical Treatment
