摘要
目的评价口服营养补充对血液透析营养不良患者营养评价指标的影响。方法计算机检索CochraneLibrary、PUBMED、EMBASE、中国生物医学文献数据库（CBM）、中国知网全文数据库（CNKI）、中国科技期刊数据库（VIP）和万方数据库中关于口服营养补充对血液透析营养不良患者效果的随机对照试验，并追溯合格研究、主题相关研究和综述的参考文献。2名评价者独立检索、筛查文献、提取数据、评价纳入文献的方法学质量并交叉核对后．用RevMan5．2软件行meta分析。结果口服营养补充可使患者的血白蛋白升高[WMD=1．99，95％CI（1．41～2．57），P〈0．001]、前白蛋白升高[WMD=34．48，95％CI（25．58～43．39），P〈0．001]，对体质指数无影响[WMD=0．44，95％CI（-0．39～1．26），P=0．30]，不会升高血磷[WMD=0．08，95％CI（-0．08～0．24），P=0．31]和血钾[WMD=0．12，95％CI（0．08-0．32），P=0．26]。结论口服营养补充可短期内改善患者的部分营养指标但对BMI值没影响，且不会引起血钾血磷升高，是一种安全有效的营养干预方法。
Objective To assess the effects of oral nutritional supplement（ONS） on malnutrition status in patients with haemodialysis. Methods A computerized search in Cochrane Library,PUBMED,EMBASE,Chinese Biomedical Literature Database （CBM）,China Academic Journal Full-Text Database （CNKI）,VIP and Wangfang Database was performed for relevant randomized controlled trials（RCTs） which investigated the effects of ONS on malnutrition sta- tus in patients with haemodialysis. We manually searched the lists of references of eligible articles, topic-related literature and reviews to include any latent studies. Target databases were searched and data were extracted, and methodological quality of all eligible studies was assessed accordingly by 2 independent investigators. Any diver- gences on eligibility of studies were solved based on consensus. Meta-analysis was performed using RevMan 5.2. Results A total of 6 RCTs which included 231 participants were incorporated into the meta-analysis. The meta- analysis results suggested that oral nutritional supplement effectively elevated blood album concentrations [WMD= 1.99 ,95%CI （1.41-2.57 ） ,P〈0.001 l ,prealbum coneentrations [ WMD=34.48,95%CI （ 25.58-43.39 ） ,P〈0.001] ,but had no impact on BMI[WMD=0.44,95%CI（-0.39-1.26）,P=0.30],and had no elevation effect on serum phosphate concentration [WMD=0.08,95%CI（-0.08-0.24）,P=0.31] and serum potassium concentration[WMD=0.12,95%CI（-0.08-0.32）, P=0.26]. Conelusion ONS can improve some nutrition indicators in short term but has no effect on BMI,and does not elevate blood potassium and phosphorus concentration,so it＇s a safe and effective nutrition intervention method.
出处
《中华护理杂志》
CSCD
北大核心
2015年第12期1425-1431,共7页
Chinese Journal of Nursing
关键词
透析
肠道营养
蛋白质能量营养不良
Renal dialysis
Enteral Nutrition
Protein-Energy malnutrition
