摘要
目的:总结上海市艾滋病患者接受国家免费抗逆转录病毒治疗(anti-retroviral therapy,ART)后药物不良反应的发生情况并分析其影响因素。方法:采用回顾性研究方法,对上海市公共卫生临床中心2009年1月1日至2013年6月30日纳入免费ART项目的872例艾滋病患者进行研究,所有患者定期进行药品不良反应临床和实验室评估。结果:在治疗过程中82.80%的患者出现药物相关不良反应,常见的短期药物不良反应有消化系统症状、皮疹、骨髓抑制、中枢神经系统症状等,中长期药物不良反应有肝毒性、外周神经炎、脂肪重新分布等。齐多夫定(zidovudine,AZT)与消化系统症状、贫血,司他夫定(stavudine,D4T)与脂肪重新分布,依非韦仑(efavirenz,EFV)和奈韦拉平(nevirapine,NVP)与皮疹、肝毒性间有一定的特异关联性。结论:临床医生应针对患者特征选择适当的治疗方案以减少药物不良反应的发生,并应熟悉药物不良反应的相关处理。
OBJECTIVE To summarize adverse reactions of national free anti retroviral therapy （ART） drugs in All）S pa tients in Shanghai,and analyze relevant influencing factors. METHODS Retrospective review was adopted to investigate 872 AIDS patients enrolled in free ART program from January I st 2009 to June 30th 2013 in Shanghai Public ftealth Clinical Cen ter. All patients were regularly assessed by clinical and experimemal evaluations on adverse drugs reactions. RESUL＇IS During therapeutic course, 82. 80% patients had adverse drug reactions. Common short term adverse drug reactions included digestive symptoms, skin rash,marrow inhibition, symptoms of central nervous system, medium and long term adverse reactions included hepatic toxicity,peripheral neuritis, fat redistribution, etc. Zidovudine （AZT） had certain special relationsbip with digestive symptoms and anemia,stavudine （INT） with fat redistribution,efavirenz （EFV） and nevirapine （NVP） with skin rash and he- patic toxicity. CONCLUSION Clinical physicians should adopt proper therapeutic regimen based on patient characteristics to re- duce occurrence of adverse drug reactions, and be familiar with relevant management skills on adverse drug reactions.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第22期2038-2041,共4页
Chinese Journal of Hospital Pharmacy
基金
国家"重大新药创制"科技重大专项(编号:2012ZX09303016)
