摘要
目的探讨不同时间点检测血清降钙素原(PCT)、和肽素(copeptin)水平在脑出血合并肺部感染患者中的临床意义。方法选取该院2013年1月至2014年6月期间诊断为脑出血、脑出血合并肺部感染患者共76例及同期体检的健康者30例(健康对照组),比较脑出血组和脑出血合并肺部感染组在发病后不同时间点以及健康对照组血清PCT与和肽素水平的差异。应用受试者工作特征曲线(ROC)评价二者联合检测对脑出血合并肺部感染的早期诊断价值。结果脑出血合并肺部感染组在发病后6、24h及7、14dPCT、和肽素水平均高于脑出血组和健康对照组,差异有统计学意义(P<0.05)。ROC曲线显示,单项检测中PCT、和肽素的曲线下面积(AUC)分别为0.734和0.727,PCT的曲线下面积略大于和肽素,PCT、和肽素联合检测时,曲线下面积增加到0.841。结论血清PCT、和肽素均可作为脑出血合并肺部感染早期诊断有价值的参考标志物,联合检测血清PCT、和肽素水平对脑出血合并肺部感染的早期诊断价值高于单一指标。
Objective To investigate the clinical significance of PCT（serum concentration of procalcitonin） and copeptin at different time points in cerebral--hemorrhaged patients with-pulmonary infection. Methods 76 patients with acute cerebral hemor- rhage and patients with cerebral hemorrhage complicated with pulmonary infection as well as 30 healthy individuals （the control group） in our hospital from January 2013 to June 2014 were selected and detected serum procalcitonin and copeptin at different time points. The differences of serum procalcitonin,copeptin at different time points were compared in controls,in patients with cerebral hemorrhage and cerebral hemorrhage complicated with pulmonary infection and their correlation was analyzed. The ROC curve was used to evaluate the early diagnostic value of combined examination of procalcitonin and copeptin. Results The levels of serum procalcitonin and copeptin in the cerebral hemorrhage with pulmonary infection group were significantly higher than that in control group and the cerebral hemorrhage group after 6 hours, 24 hours and 7 days, 14 days , the difference had statistical significance（P〈0.05）. The area under ROC curve（AUC） of procalcitonin（0.734） was higher than those of copeptin（0. 727）. The AUC for com- bined examination of procaicitonin and copeptin was 0. 841,which was higher than single detection of procalcitonin. Conclusion Both procalcitonin and copeptin are good markers in the early diagnosis of cerebral hemorrhage complicated with pulmonary infection, combined detection of procalcitonin and copeptin levels is more valuable for early diagnosis of cerebral hemorrhage complicated with pulmonary infection.
出处
《重庆医学》
CAS
北大核心
2015年第34期4802-4804,共3页
Chongqing medicine
基金
福建省福州市科技计划基金资助项目(2012-S-154-5)
关键词
脑出血
感染
降钙素原
和肽素
早期诊断
cerebral hemorrhage
infection
procalcitonin
copeptin
early diagnosis
