摘要
近来研究表明,铁过载与骨质疏松有密切的关系。遗传性血色素沉着症和地中海贫血症等铁代谢紊乱的疾病患者中都伴随有不同程度的骨质疏松现象。另外,长期在轨飞行环境下,航天员出现机体铁沉积现象,同时,骨丢失情况十分严重,每月的骨丢失量约与地面上绝经后妇女每年的骨丢失量相当。铁水平升高能够抑制成骨细胞的分化,降低成骨细胞功能,成骨能力下降,骨形成受到抑制。铁沉积的同时,能够促进破骨细胞活性,增强骨吸收的能力,造成机体骨量减少,导致骨质疏松。铁调素能够作用于成骨细胞,随着铁调素剂量的增加,成骨细胞中与骨形成相关的基因表达量明显升高。铁调素还能作用于破骨细胞,促进破骨细胞的分化。在预防和治疗骨质疏松方面,有实验证明,铁螯合剂和铁调素都有治疗骨质疏松的作用。利用铁调素调节机体铁代谢平衡,降低铁过载程度,为日后临床治疗骨质疏松提供了理论支持。
Recent researches indicate that iron overload is closely related with osteoporosis. Osteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. Furthermore, long-duration space flight can increase body iron stores and induce bone loss in astronauts. Iron overload can inhibit osteoblast differentiation and function, which leads to reduced bone formation. Meantime, iron overload can enhance osteoclast function and increase bone absorption. Thus, iron overload can induce osteoporosis. Hepcidin has been found to be a main regulator of iron homeostasis, recent studies demonstrate that liver hepcidin level is associated with osteoporosis. Hepcidin can regulate osteoblast function, and enhance the bone formation gene expression in a dose dependent manner. Moreover, hepcidin can significantly facilitate osteoclast differentiation in vitro. As iron overload and osteoporosis are closely associated, the approaches for decreasing iron overload may have clinical potential for treatment and prevention of osteoporosis.
出处
《生命科学》
CSCD
2015年第10期1280-1284,共5页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(ZRJJ140602)
关键词
骨质疏松
铁过载
铁调素
osteoporosis
iron overload
hepcidin
