子宫内膜异位症患者异位内膜中c-IAP1的表达及意义被引量：10

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摘要目的分析c-IAP1在子宫内膜异位症中的表达情况及与临床之间的关系,了解c-IAP1在子宫内膜异位症发病机制中的作用。方法收集人体新鲜组织标本,利用RT-PCR的检测手段测定c-IAP1在22例子宫内膜异位症患者异位灶（观察组）和10例正常人子宫内膜（对照组）的表达差异。收集到卵巢巧克力囊肿标本共20例,腹壁型子宫内膜异位症患者2例,单独列出。在手术中采用R-AFS分期法进行分期,将患者分为轻度组（Ⅰ~Ⅱ期）共8例、重度组（Ⅲ~Ⅳ期）共12例。结果对照组与观察组患者c-IAP1扩增水平比较差异有统计学意义（P〈0.05）。重度组与其他组织c-IAP1扩增水平比较差异有统计学意义。子宫内膜异位症患者有腹痛症状患者的c-IAP1表达高于无腹痛患者,差异有统计学意义。结论 c-IAP1在子宫内膜异位症患者异位灶中有较高表达,表达升高程度与疾病的严重程度呈正相关,而且与疾病临床表现相关。

作者王燕

机构地区郑州大学第二附属医院妇产科

出处《广东医学》 CAS 北大核心 2015年第21期3344-3347,共4页 Guangdong Medical Journal

关键词凋亡抑制蛋白子宫内膜异位症凋亡

分类号 R711.71 [医药卫生—妇产科学]

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