摘要
目的探讨伏立康唑治疗严重烧伤并发真菌感染临床效果及安全性,为临床治疗提供参考。方法选择2012年1月-2014年12月48例严重烧伤并发真菌感染患者,按照数字表法分为对照组与观察组,对照组22例使用氟康唑治疗,观察组26例使用伏立康唑治疗;分析患者临床特征,对比两组患者治疗后临床效果及不良反应。结果 48例患者拟诊30例、16例患者确诊,共检出真菌24株,白色假丝酵母菌12株、曲霉菌属6株;观察组治疗有效率80.77%,明显高于对照组的68.18%,两组差异有统计学意义(χ2=5.978,P<0.01);观察组并发症发生率15.38%,低于对照组,两组比较差异有统计学意义(χ2=7.383,P<0.01);两组患者降钙素原、C-反应蛋白治疗后相比治疗前均有显著改善(P<0.05);观察组降钙素原、C-反应蛋治疗后相比对照组改善更明显(P<0.05)。结论伏立康唑治疗严重烧伤并发真菌感染临床效果显著,不良反应少,值得临床推广应用。
OBJECTIVE To explore the clinical efficacy and safety of voriconazole in treatment of the severe burns patients with fungal infections so as to provide guidance for clinical treatment. METHODS A total of 48 severe burns patients complicated with fungal infections who were treated in the hospital from Jan 2012 to Dec 2014 were enrolled in the study and randomly divided into the control group and the observation group. The control group with 22 cases was treated with fluconazole, while the observation group was treated with voriconazole. The clinical characteristics of the patients were analyzed; the clinical therapeutic effect and incidence of adverse reactions were observed and compared between the two groups of patients. RESULTS Of the 48 patients, 30 cases were suspec- ted, and 16 cases were confirmed. Totally 24 strains of fungi were isolated, including 12 strains of Candida albi- cans and 6 strains of Aspergillus. The effective rate of treatment of the observation group was 80.77%, signifi- cantly higher than 68.18 % of the control group （x^2= 5. 978, P〈0.01）. The incidence of complications of the ob- servation group was 15.38%, signigiceatly lower than that of the control group （x^2 =7. 383 ,P〈0.01）. The levels of PCT and CRP of the two groups of patients were significantly improved after the treatment （P〈0.05）, and the levels of PCT and CRP of the observation group were improved more significantly than those of the control group （P〈0.05）. CONCLUSION Voriconazole can achieve remarkable clinical effect on treatment of the severe burns pa- tients complicated with !ungal infections, with the incidence of adverse reactions low, and it is worthy to be pro- moted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第23期5380-5382,共3页
Chinese Journal of Nosocomiology
基金
深圳市科技局基金资助项目(201103070)
关键词
伏立康唑
烧伤
真菌
感染
Voriconazole
Burn
Fungus
Infection
