摘要
目的探讨不同方案保守治疗异位妊娠（EP）的疗效。方法回顾性分析该院2012年6月至2014年6月经药物保守治疗的198例EP患者的病历资料,根据治疗方案分为A组（39例）单用甲氨蝶呤（MTX）,B组（92例）MTX联合米非司酮用药,C组（67例）采用MTX 8日疗法,观察各组治愈率、人绒毛膜促性腺激素β亚单位（β-HCG）下降至正常水平时间等,比较3种方案的疗效,以及不同血β-HCG水平对3种方案的影响。结果3组治愈率比较差异有统计学意义（P〈0.05）,最高为C组（86.57%）,B组次之（84.78%）,A组最低（66.67%）。3组患者中β-HCG水平为1 500~3 000mIU/mL者及大于3 000mIU/mL者治愈率比较,差异均有统计学意义（P〈0.05）。结论单用MTX保守治疗EP效果欠佳,推荐选用联合方案或8日疗法,较高β-HCG水平患者采用8日疗法疗效最好。
Objective To explore the therapeutic efficacy of three different treatment regimens for conservative treatment of ectopic pregnancy（EP）.Methods Clinical data of 198 cases of patients with EP who were conservatively treated in this hospital from June 2012 to June 2014 were retrospectively analysed.All patients were divided into group A（39 cases）,group B（92 cases）and group C（67 cases）,which were treated with single-dose of methotrexate（MTX）,MTX combined with mifepristone and multipledose of MTX respectively.The curative rate and time for human chorionic gonadotropin beta-subunit（β-HCG）dropping to normal were observed and recorded.Results The total curative rates in three groups were statistically different（P〈0.05）,additionally,group C had the highest curative rate（86.57%）,followed by group B with 84.78% and group A with 66.67%.In the three groups,for patients with serum level ofβ-HCG 1 500-3 000mIU/mL or3 000mIU/mL,the curative rates were statistically different（P〈0.05）.Conclusion Single-dose of MTX has relative low curative rate.It is recommend to use combination regimens or multiple-dose of MTX regimens,and for patients with high level ofβ-HCG multiple-dose of MTX regimens might be the best choice.
出处
《国际检验医学杂志》
CAS
2015年第23期3439-3441,共3页
International Journal of Laboratory Medicine
关键词
异位妊娠
保守治疗
甲氨蝶呤
米非司酮
ectopic pregnancy
conservative treatment
methotrexate
mifepristone
