摘要
肝癌是一种恶性肿瘤,目前的手术、放化疗均不能取得满意疗效,复发、转移一直是肝癌治疗的难题。根据近些年研究的肝癌干细胞学说,肝癌的发生、发展、复发、转移、预后都与肝癌干细胞有关。如果靶向作用于肝癌的干细胞,使其数目减少或者被消灭掉,就会使肿瘤切除术后的复发、转移性及耐药性降低或被清除。对肝癌干细胞的靶向治疗进展情况作一综述,认为肝癌干细胞的靶向治疗方法虽然有很多种,但是靶向性不强仍然是亟需解决的关键问题,是否可以通过双靶向或者多靶向联合解决靶向性的问题还需要进一步的实验研究证实。
Liver cancer is a malignant tumor. The current operation or chemoradiotherapy cannot achieve a satisfactory effect, and relapse and metastasis are always big problems in the treatment of liver cancer. According to the recent theory of liver cancer stem cells, the genesis, development, relapse, metastasis, and prognosis of liver cancer are all related to liver cancer stem cells. If the liver cancer stem cells are treated by targeted therapy, which would reduce the number of or destroy the stem cells, the relapse, metastasis, and drug resistance after tumor resection may be reduced or eliminated. The progress in targeted therapy for liver cancer stem cells is reviewed here. Although there are many types of targeted therapies for liver cancer stem cells, it is still a key problem that the targeting is not strong enough, which needs to be solved urgently. Whether the dual - or multi -targeting would solve this problem still needs to be confirmed by further experimental studies.
出处
《临床肝胆病杂志》
CAS
2015年第11期1933-1936,共4页
Journal of Clinical Hepatology
关键词
肝肿瘤
肿瘤干细胞
治疗
综述
liver neoplasms
neoplastic stem cells
therapy
review
