摘要
【目的】探讨米非司酮对子宫肌瘤患者术后激素水平和复发的影响。【方法】选择手术治疗的子宫肌瘤患者440例，按入院顺序分为对照组和观察组，每组220例。对照组患者仅做子宫肌瘤剔除术，观察组患者在子宫肌瘤剔除术后服用米非司酮辅助治疗。比较两组患者术后1个月及12个月卵泡后期血清卵泡刺激素（FS H ）、雌二醇（E2）及孕酮（P ）的水平；记录两组患者术后月经恢复时间、阴道出血时间及术后3个月、6个月、12个月及24个月子宫肌瘤的复发率，并随时监测观察组患者在术后服药期间不良反应的发生情况。【结果】观察组术后1个月的血清FS H、E2及P水平显著低于对照组（ P ＜00．5），术后12个月观察组血清FS H、E2及P水平与对照组比较无显著性差异（ P ＞00．5）；观察组月经恢复时间明显长于对照组，术后阴道出血时间明显短于对照组，术后24个月内的总复发率明显低于对照组，其差异均有统计学意义（ P ＜00．5）。观察组随访期间无明显不良反应。【结论】米非司酮可预防子宫肌瘤剔除术后再复发，对激素水平无影响，不良反应小，值得临床推广应用。
Objective]To study the preventive effect of mifepristone on recurrence patients with myoma of u‐terus after undergoing resection operation .[Methods]Four hundred and forty patients with uterine myomectomy treated in our hospital were selected as subjects of study .Members of the observation group and the control group were decided according to order of admission ;each group had 220 cases .Patients in the control group underwent only the myomectomy ,while the observation group patients took mifepristone treatment after their myomectomi‐es .Serum follicle stimulating hormone （FSH ） ,estradiol （E2 ） ,and progesterone （P） of one month and twelve months post‐operation were measured in patients of these two groups .Time until the recovery of menstruation and vaginal bleeding after operation and the rate of recurrence of uterine myoma 3 ,6 ,12 ,and 24 months after opera‐tion were compared between two groups .Postoperative adverse reactions were closely monitored and recorded in the observation group patients during treatment .[Results]The FSH ,E2 ,and P levels of the patients in the obser‐vation group one month after operation were significantly reduced further than those of the control group patients . The levels twelve months post‐operation gradually returned to the levels of the control group .The menstrual re‐covery time of the observation group was significantly longer than that in the control group ,with significant differ‐ence （ P ＆lt;0 0.5） .The vaginal bleeding time of the study group was significantly shorter than that of the control group ,with significant difference （ P ＆lt;0 0.5） .The total rate of relapse in the observation group after 24 months post‐operation were significantly lower than that of the control group ,with statistically significant differences .[Conclusion]Mifepristone is an effective prevention drug for recurrence in patients with myoma of uterus after re‐section operation .
出处
《医学临床研究》
CAS
2015年第11期2210-2212,共3页
Journal of Clinical Research
