摘要
目的观察参附注射液对急性心肌梗死患者经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后低血压状态的治疗作用。方法将62例入选患者按随机数字表法随机分为两组,均常规冠状动脉粥样硬化行心脏病(冠心病)二级预防、应用多巴胺升压治疗,治疗组(33例)加用参附注射液100 m L静脉注射,每日一次;对照组给予0.9%氯化钠溶液100 m L静脉注射,每日一次。比较两组多巴胺剂量、使用时间、不良反应,观察临床疗效。结果治疗组使用多巴胺剂量明显低于对照组,差异有统计学意义[(4.67±1.47)μg·kg^(-1)·min^(-1)vs.(5.80±1.67)μg·kg^(-1)·min^(-1),P<0.05]。治疗组使用多巴胺时间较对照组明显缩短,差异有统计学意义[(41.97±23.20)h vs.(65.00±26.35)h,P=0.01]。治疗组心力衰竭、心律失常的发生率较对照组明显降低;治疗组在治疗过程中能更早加用美托洛尔、福辛普利等心脏保护药物。结论参附注射液既有较好的升压作用,又能保护心肌缺血再灌注损伤、改善心脏功能、减少多巴胺用量及其不良反应,是治疗急性心肌梗死PCI后低血压的理想药物。
Objectives To observe the efficacy of shenfu injection for hypotension in patients with acute myocardial infarction （AMI） after pereutaneous coronary intervention （PCI）. Methods Totally 62 patients enrolled were randomly divided into two groups. Patients in both groups received the secondary prevention of coronary heart disease and took dopamine to increase blood pressure. Among them, 33 cases combined with shenfu injection （intravenous drip 100 mL once daily） were defined as treatment group. The other 29 cases combined with saline solution therapy （intravenous drip 100 mL once daily） were assigned as control group. Clinical efficacy, adverse events, dose and usage duration of dopamine between the two groups were compared. Results Treatment group used less dopamine than control group, and the difference was significant [（4.67±1.47）g.kg ·min-1 vs. （5.80±1.67）pug.kg-1.min-l, P〈0.05]. Usage duration of dopamine in treatment group was significantly shorter than that in control group [ （41.97±23.20） h vs. （65.00±26.35） h, P=0.01 ]. Incidences of heart failure and arrhythmia were significantly lower in treatment group than in control group. Patients in treatment group took metoprolol, fosinopril and other cardioprotective drugs earlier than patients in control group. Conclusions Shenfu injection is an ideal therapy for hypotension in patients with AMI after PCI. It can improve blood pressure level, protect myocardial isehemia-repeffusion injury, improve heart function and reduce dopamine dose and its adverse effects.
出处
《岭南心血管病杂志》
2015年第6期770-774,共5页
South China Journal of Cardiovascular Diseases
关键词
心肌梗死
参附注射液
多巴胺
治疗
低血压
血管成形术
经腔
经皮冠状动脉
acute myocardial infarction
shenfu injection
dopamine
treatment
hypotension
percutaneous coronaryintervention
