期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

和肽素及其在脑卒中评估中的应用

Copeptin and its application in stroke evaluation
原文传递
导出
摘要 脑卒中是目前严重影响我国中老年人健康的重要疾病,临床研究表明,脑卒中患者的下丘脑-垂体-肾上腺素（HPA）轴存在不同程度失调。精氨酸加压素（AVP）是下丘脑分泌的一种重要激素,在多种疾病过程及应激反应中升高明显,但其半衰期短且不易检测,限制了在临床中的应用〔1-2〕。Holwerda（1972年）首先发现了和肽素（copeptin）, Copeptin,apeptide composed of 39 amino acids,is a part of arginine vasopressin（AVP）end peptide C.It is stable and easy to be detected in vitro,and changes consistently with AVP.Therefore,copeptin can replace AVP to be used in clinical studies.Recent studies discovered that copeptin measurement has great application value in prognosis of stroke.This article reviews the recent studies of copeptin in the prognosis of troke.
作者 杨鲁 张新超
机构地区 北京医院急诊科
出处 《临床急诊杂志》 CAS 2015年第11期900-902,共3页 Journal of Clinical Emergency
关键词 和肽素 精氨酸加压素 脑卒中 copeptin arginine vasopressin stroke
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献31

  • 1Szinnai G,Morgenthaler N G,Berneis K,et al.Changes in plasma copeptin,the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects[J].J Clin Endocrinol Metab,2007,92:3973-3978.
  • 2Balanescu S,Kopp P,Gaskill M B,et al.Correlation of plasma copeptin and vasopressin concentrations in hypo-,iso-,and hyperosmolar States[J].J Clin Endocrinol Metab,2011,96:1046-1052.
  • 3Katan M,Morgeuthaler N G,Dixit K C,et al.Anterior and posterior pituitary fimetion testing with simultaneous insulin tolerance test and a novel copeptin assay[J].J Clin Endocrinol Metab,2007,92:2640-2643.
  • 4Morgenthaler N G,Struck J,Alonso C,et al.Assay for the measurement of copeptin,a stable peptide derived from the precursor of vasopressin[J].Clin Chem,2006,52:112-119.
  • 5Holwerda D A.A glycopeptide from the posterior lobe of pig pituitaries.I.Isolation and characterization[J].Eur J Biochem,1972,28:334-339.
  • 6Seligman R,Seligman B G,Teixeira P J.Comparing the accuracy of predictors of mortality in ventilator-associated pneumonia[J].J Bras Pneumol,2011,37:495-503.
  • 7Jochberger S,Luckner G,Mayr V D,et al.Course of vasopressin and copeptin plasma concentrations in a patient with severe septic shock[J].Anaesth Intensive Care,2006,34:498-500.
  • 8Struck J,Morgenthaler N G,Bergmann A.Copeptin,a stable peptide derived from the vasopressin precursor,is elevated in serum of sepsis patients[J].Peptides,2005,26:2500-2504.
  • 9Stoiser B,Mrtl D,Hülsmann M,et al.Copeptin,a fragment of the vasopressin precursor,as a novel predictor of outcome in heart failure[J].Eur J Clin Invest,2006,36:771-778.
  • 10Lippi G,Plebani M,Di Somma S,et al.Considerations for early acute myocardial infarction rule-out for emergency department chest pain patients:the case of copeptin[J].Clin Chem Lab Med,2012,50:243-253.

二级参考文献15

  • 1Ikram MA, Wieberdink RG, Koudstaal PJ. International epidemiology of intracerebral hemorrhage [J]. Curr Atheroscler Rep, 2012, 14(4): 300-306.
  • 2Rincon F, Lyden P, Mayer SA. Relationship between temperature, hematoma growth, and functional outcome after intracerebral hemorrhage[J]. Neurocrit Care, 2013, 18(1): 45-53.
  • 3Lee JH, Chan YH, Lai OF, et al. Vasopressin and eopeptin levels in children with sepsis and septic shock [J]. Intensive Care Med, 2013, 39(4): 747-753.
  • 4De Marchis GM, Katan M, Weck A, et al. Copeptin adds prognostic information after ischemic stroke: results from the CoRisk study [J]. Neurology, 2013, 80(14): 1278-1286.
  • 5Fung C, De Marchis GM, Katan M, et al. Copeptin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage[J]. PLoS One, 2013, 8(1):e53191.
  • 6Dong XQ, Huang M, Yu WH, et al. Change in plasma copeptin level after acute spontaneous basal ganglia hemorrhage [J]. Peptides, 2011, 32(2): 253-257.
  • 7Dong XQ, Huang M, Yang SB, et al. Copeptin is associated with mortality in patients with traumatic brain injury [J]. J Trauma, 2011, 71(5): 1194-1198.
  • 8Barat C, Simpson L, Breslow E. Properties of human vasopressin precursor constructs: inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus [J]. Biochemistry, 2004, 43(25): 8191-8203.
  • 9Benarroch EE. Oxytocin and vasopressin: Social neuropeptides with complex neuromodulatory functions [J]. Neurology, 2013, 80(16): 1521-1528.
  • 10Giannopoulos G, Deftereos S, Panagopoulou V, et al. Copeptin as a biomarker in cardiac disease[J]. Curr Top Med Chem, 2013, 13(2): 231-240.

共引文献8

临床急诊杂志
2015年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部