摘要
目的:探讨干扰素联合布地奈德治疗毛细支气管炎的疗效。方法:将153例婴幼儿毛细支气管炎患儿随机分为治疗组和对照组。治疗组给予干扰素联合布地奈德雾化治疗,对照组给予利巴韦林联合地塞米松雾化治疗;两组均辅以退热、止咳及必要时抗生素等对症支持治疗。比较两组患儿治疗后发热、喘息、肺部哮鸣音情况、住院天数以及随访2年后喘息症状的再发生率和平均发生次数(次/人·年-1)。结果:两组治疗后发热、喘息、肺部哮鸣音明显缓解,治疗组症状缓解速度、程度均优于对照组(P<0.05),住院天数少于对照组(P<0.05);治疗组2年后随喘息症状再发生率和平均发生次数明显低于对照组。结论:干扰素联合布地奈德治疗毛细支气管炎疗效肯定,能迅速缓解和控制临床症状,减少喘息再发生率和平均发生次数。
Objective： To investigate the effect interferon combined with budesonide on the treatment of capillary bronchitis curative. Method： One hundred and fifty-three cases of infants with capillary bronchiolitis were randomly divided into the treatment group and the control group. The treatment group were given interferon combined with budesonide atomization and control group were given ribavirin combined with dexamethasone aerosol therapy. Two groups were supplemented with fever,cough,even the symptomatic support treatment such as antibiotics when necessary. After treatment fever,wheezing,lung wheezing sound,hospitalization days were compared between the two groups; and wheezing symptoms recurrence rate and average frequency（ times / person·years^-1） after 2 years were followed up. Results： After treatment of fever,wheezing and lung wheezing sound were obviously relieved in two groups. Symptoms relief speed,degree and the hospitalization days in the treatment group was better than those of control group（ all P〈0. 05）; After 2 years of follow-up wheezing symptom recurrence rate and average occurrence frequency in treatment group were significantly lower than those in control group. Conclusion： Interferon combined with budesonide in the treatment of capillary bronchitis curative has an affirmative effect. It can rapidly relieve and control the clinical symptoms,reduce wheezing symptoms reoccurrence rate and average occurrence frequency reduced also.
出处
《现代医学》
2015年第10期1275-1277,共3页
Modern Medical Journal
关键词
干扰素
布地奈德
毛细支气管炎
疗效
随访
interferon
budesonide
bronchiolitis
curative effect
follow-up
