摘要
基于自适应光学(AO)像差校正技术的激光共聚焦扫描检眼镜是当前研究的热点,为眼底疾病早期诊断提供有力的支持。利用可连续变形镜和夏克-哈特曼探测器为核心器件搭建了一套高帧频紧凑型自适应光学扫描激光检眼镜(AOSLO)系统,系统物理尺寸为350 mm×400 mm,图像采集帧频为40 fps,分别进行了系统分辨率测试与人眼视网膜成像初步实验。结果表明,系统人眼视网膜面上的分辨率可达到2.50μm,达到极限分辨率(2.32μm),可实现细胞量级高分辨率成像,自适应光学系统能够校正人眼像差,校正前后图像质量有明显的提高,能清楚地观察到人眼视网膜视盘附近的血管以及黄斑区细胞图像。
Confocal scanning laser ophthalmoscopy based on adaptive optics （AO） aberration correction technology is the recent research focus, and provides powerful support in early diagnosis of ocular fundus diseases. A high- speed compact adaptive optics scanning laser ophthalmoscope （AOSLO） is built by employing deformable mirrors and Shack-Hartmann wavefront sensors, with 350 mm × 400 mm system size and 40 fps frame rate of image collection. The system resolution measurement and human retinal imaging experiments are carried out respectively, and the results indicate that the real resolution in human retina of this system is 2.50 μm, close to the diffraction limit resolution which is 2.32 μm, and the system can be used to image the retina at cell level. Meanwhile, the experimental results show that the adaptive optics system can correct aberration of human eyes, image quality is significantly improved after AO, and the retinal blood vessels near optic disc and retina cones in fovea region for human eyes are observed clearly.
出处
《光学学报》
EI
CAS
CSCD
北大核心
2015年第11期243-252,共10页
Acta Optica Sinica
基金
国家科技支撑计划(2012BAI08B04)
国家自然科学基金(81300804)
温州医科大学科研发展基金(QTJ11022)
