摘要
目的：探讨我院碳青霉烯类抗菌药所致不良反应的特点及相关因素,为临床合理用药提供参考。方法：对我院2008年3月1日~2014年8月1日上报的因使用碳青霉烯类抗菌药出现的不良反应报告进行统计分析。结果：由碳青霉烯类引起的不良反应共73例。发生不良反应的男女例数相当,80岁以上人群发生不良反应例数较多。用药第1天发生不良反应例数较多。不良反应主要为皮肤及其附件损害、神经系统损害。结论：临床应重视碳青霉烯类抗菌药的不良反应,用药时注意患者的临床表现对于肾功能减退、患神经系统基础疾病的患者及时调整用药方案。减少不良反应的危害。
Objective： To investigate the adverse drug reactions （ADR） caused by carbapenem antibiotics and discuss the influen- cing factors to provide reference for the rational use of carbapenems in clinics. Methods： The ADR caused by carbapenems from March 1,2008 to August 1,2014 in our hospital were statistically analyzed. Results： Totally 73 cases of ADR were caused by carbapenems. The number of ADR for men and women was similar. The ADR occurred in 80-year-old people with more frequency. The incidence of ADR on the first day of administration was relative high. The ADR were mainly manifested as skin and appendages disorders and nerve system damage. Conclusion： Great attention should be paid to the ADR of carbapenems and the state of patients. The medication should be adjusted in the patients with declined renal function and nerve system basic diseases in order to reduce the damage of ADR.
出处
《中国药师》
CAS
2015年第12期2119-2122,共4页
China Pharmacist
