摘要
目的：探讨糖皮质激素治疗支气管哮喘临床效果及对血清学指标影响，为临床治疗提供参考。方法选择支气管哮喘患者40例，按照数字表法随机分为观察组与对照组各20例。观察组使用孟鲁司特联合布地奈德雾化吸入治疗，对照组仅使用孟鲁司特治疗，比较两组治疗后肺功能、血清白细胞介素、血清一氧化氮、一氧化氮合成酶指标。结果观察组治疗后 FVC％、FEV1％、PEF％分别为（83．67±5．57）％、（89．92±6．37）％、（88．01±6．04）％，改善均优于对照组，差异有统计学意义（两组治疗后比较，tFVC ＝3．537，tFEV1＝3.119，tPEF ＝3．354，均 P ＜0．05）；观察组治疗后 IL-4、IL-13、NO、NOS 分别为（4．79±0．89）pg／mL、（26．64±3.32）pg／mL、（61．13±4．49）μmol／L、（33．34±2．81）U ／mL，改善均优于对照组，差异有统计学意义（两组治疗后比较，tIL-4＝3．214，tIL-13＝4．051，tNO ＝3．815，tNOS ＝3．904，均 P ＜0．05）。结论孟鲁司特联合糖皮质激素治疗支气管哮喘临床效果好，利于改善血清炎性指标，值得临床推广应用。
Objective To investigate the clinical effect of glucocorticoid in the treatment of bronchial asthma and its influence on serum markers,to provide a reference for clinical treatment.Methods 40 cases with bronchial asthma were selected,and they were randomly divided into observation group and control group,20 cases in each group.The observation group was given montelukast and budesonide inhalation therapy,the control group received montelukast therapy.The lung function after treatment,serum interleukins,serum nitric oxide,the rate -limiting enzyme targets were compared.Results After treatment,FVC%,FEV1 %,PEF% in the observation group were （83.67 ±5.57）%,（89.92 ±6.37）%,（88.01 ±6.04）% respectively,the improvement was better than the control group,the difference was statistically significant（comparison after treatment between the two groups tFVC =3.537;tFEV1 =3.119;tPEF =3.354,all P ＆lt;0.05）.After treatment,IL -4,IL -13,NO,NOS of the observation group were （4.79 ± 0.89）pg/mL,（26.64 ±3.32）pg/mL,（61.13 ±4.49）μmol/L,（33.34 ±2.81 ）U /mL,respectively,the improve-ment was better than the control group,the difference was statistically significant（comparison after treatment between the two groups tIL -4 =3.214;tIL -13 =4.051;tNO =3.815;tNOS =3.904,all P〈0.05）.Conclusion Montelukast combined with glucocorticoids in the treatment of bronchial asthma has good clinical results,which will help to improve the serum inflammatory markers,it is worthy of clinical application.
出处
《中国基层医药》
CAS
2015年第23期3646-3648,共3页
Chinese Journal of Primary Medicine and Pharmacy
