摘要
目的:探讨超声引导下射频热疗联合适形放疗治疗肝癌的近远期疗效。方法:连续收集我院2012年3月至2014年3月收治的80例肝癌患者的临床资料,患者均经临床表现、影像、生化检查及病理确诊为原发性肝癌。该研究取得我院伦理委员会通过及患者、家属的知情同意权后,依据随机数字表法将患者分为对照组和观察组,每组40例。对照组给予单纯适形放疗,观察组在对照组的基础上联合使用超声引导下射频热疗,对两组患者近期及远期疗效进行比较和分析。结果:两组患者治疗前胆红素、白蛋白、ALT和PT水平比较,差异均无统计学意义(P>0.05);治疗后两组患者的胆红素、ALT和PT水平均降低,且试验组降低的更明显,白蛋白水平均升高,且试验组升高的更明显,差异均有统计学意义(P<0.05)。观察组患者的总有效率显著高于对照组,差异有统计学意义(P<0.05)。随访发现,观察组患者6个月和1年的肿瘤复发率及患者的病死率均显著低于对照组,差异均有统计学意义(P<0.05)。结论:超声引导下射频热疗联合适形放疗治疗肝癌近远期效果显著,有效降低了放疗对肝脏的损害,患者耐受度较高,提高了患者远期生存率。
Objective：To study the short and long term effect of radiofrequency hyperthermia combined with ultra- sound - guided conformal radiotherapy in treatment of liver cancer. Methods ： A total of 80 conseeutives diagnosed as liver cancer from March 2012 to March 2014 were individed randomly into control and experiment groups,each of 40 cases. The patients in control group received single ultrasound - guided conformal radiotherapy, the patients in experi- ment group received radiofrequency hyperthermia combined with coirformal radiotherapy, compare the short and long term effects. Results：The Bilirubin, albumin and ALT, PT levels before treatment in the two groups were no statistical difference（ P 〉 0.05 ）. The Bilirubin, ALT, PT levels after treatment were all lower and albumin was higher in the two groups and they in experiment group were significantly more improvements than control group （ P 〈 0.05 ）. The total efficacy rate in experiment group was significantly higher（ P 〈 0.05 ）. The tutor recurrence rate and fatality rate after 6 months and one - year in experiment group were all significantly lower （ P 〈 0. 05 ）. Conclusion ： Radiofrequency hyperthermia combined with conformal radiotherapy could greatly improve short and long term effeets in patients with liv
出处
《现代肿瘤医学》
CAS
2016年第1期88-91,共4页
Journal of Modern Oncology
基金
湖北省教育厅科学研究计划项目(编号:Q20132106)
关键词
射频热疗
适形放疗
肝癌
近远期疗效
ultrasound - guided radiofrequency hyperthermia, conformal radiotherapy, liver cancer, short and longterm effect
