摘要
2018年是自1918年H1N1“西班牙流感”首次流感大流行以来第100周年。与近代历史上致命的大流行有关的流感,一般由人畜共患流感病毒引起,通过累积变异跨越动物-人类屏障,导致人类流感,临床表现可以从轻微的呼吸道疾病到多器官功能障碍。H7N9禽流感病毒跨越动物——人类屏障在中国已引起五波流感大流行,死亡率较高。目前仅存在有限的人传人,但如果它们能够有效地完成人与人之间传播,特别是通过空气传播,无疑将引发新的大流行。因此,本综述系统地阐述了H7N9禽流感病毒的结构、流行病学情况、病毒变异及感染传播的可能发病机制。
This is the 100th anniversary of the first influenza pandemic of the H1N1 "Spanish flu" in 1918.In general,influenza associated with a deadly pandemic is caused by zoonotic influenza viruses that cross the animal-human barrier through cumulative gene mutation.The induced human influenza appeared from mild respiratory disease to multiple-organ dysfunction.H7N9 avian influenza has caused five"waves"of influenza pandemics in China and with high mortality.There are only limited cases of transmission between individuals until now.However,if these viruses can be transmitted through air among individuals,a new pandemic will be triggered.This review described the possible pathogenesis of human-infected with influenza viruses(focusing on the H7N9 influenza virus),their epidemiology,viral variation,and infection transmission.
出处
《病毒学报》
CAS
CSCD
北大核心
2018年第6期904-910,共7页
Chinese Journal of Virology
基金
国家青年自然基金(项目号:31500138),题目:甲型H7N9禽流感神经氨酸酶耐药分子机理和传播性研究
国家重点研发计划(项目号:2016YFC1200204),题目:分子标记技术指标体系的建立及其临床验证~~
关键词
甲型流感
流感大流行
抗原漂移
空气传播
高致病性禽流感
Influenza A
Influenza pandemic
Antigenic drift
Airborne
Highly pathogenic avian influenza
