摘要
目的探讨不孕症患者促甲状腺素(TSH)水平变化对体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)结局的影响。方法选择行IVF/ICSI治疗的不孕症患者共69例,血清TSH水平≤2.5 m U/L的患者纳入低TSH组(n=29)。TSH>2.5 m U/L且≤5.0 m U/L的患者(n=40)进行左旋甲状腺素片预治疗。治疗后,TSH<2.5 m U/L的患者,归入治疗成功组(n=17);TSH未降至2.5 mU/L以下的患者则归入治疗未成功组(n=23)。比较各组TSH水平变化对IVF/ICSI-ET结局的影响。结果治疗未成功组在受精卵数、正常受精率、卵裂率与治疗成功组和低TSH组相比,无统计学差异(P>0.05),但优质胚胎数、胚胎种植率、临床妊娠率和早期流产率显著低于治疗成功组和低TSH组。结论对于2.5 mU/L<TSH≤5.0 mU/L的不孕患者应积极治疗,降低TSH水平,对改善IVF/ICSI-ET结局具有重要意义。
Objective To investigate the effects of thyroid stimulating hormone（ TSH） levels for in vitro fertilization / intracytoplasmic sperm injection- embryo transfer（ IVF / ICSI- ET） outcome in infertility. Methods 69 patients with infertility undertaken IVF / ICSI treatment were divided into low TSH group（ ≤2. 5 m U / L）（ n = 29） and patients with 2. 5 m U/L 〈 TSH≤5. 0 m U / L（ n = 40） were pretreated with levothyroxine tablets. After treatment,they were divided into success group（ TSH 〈 2. 5 m U / L）（ n = 17） and treatment non- success group（ TSH 〉2. 5 m U / L）（ n = 23）. Effect of TSH levels on IVF / ICSI- ET outcomes was compared. Results In treatment non- success group,the number of fertilized eggs,normal fertilization rate and cleavage rate had no significant difference with treatment success group and low TSH group. But the high quality embryos,implantation rate,clinical pregnancy rate and early abortion rate were significantly lower than the treatment success group and the low TSH group. Conclusion For infertile patients with 2. 5 m U / L 〈 TSH≤5. 0 m U / L,we should actively treat them to reduce TSH levels,which is important to improve IVF / ICSI- ET outcome.
出处
《临床和实验医学杂志》
2015年第24期2067-2070,共4页
Journal of Clinical and Experimental Medicine
关键词
不孕症
体外受精-胚胎移植
卵胞浆内单精子注射
促甲状腺素
Infertility
In vitro fertilization-embryo transfer
Intracytoplasmic sperm injection
Thyroid stimulating hormone
