摘要
目的观察谷氨酰胺对创伤性应激性胃肠道溃疡的临床疗效。方法 90例创伤性应激性胃肠道溃疡患者随机分为2组,对照组45例,给予常规西医治疗,试验组45例,在对照组的基础上加用谷氨酰胺50 m L+0.9%氯化钠250m L,静脉滴注。2组均用药10 d。观察2组患者的临床疗效、内镜下黏膜病变情况和治疗3,5,7,9 d的p H变化情况。结果治疗后,对照组显效率46.67%,总有效率82.23%;试验组显效率64.44%,总有效率91.12%,差异有统计学意义(P<0.05)。治疗前2组患者胃肠道黏膜均发生病变,治疗后2组黏膜无病变例数均显著升高,试验组显著高于对照组;轻度、中度、重度和特重病变的例数均显著下降(P<0.05);试验组的中度、重度病变例数均显著低于对照组(P<0.05)。2组治疗后3,5,7,9 d的p H值均较治疗前显著下降(P<0.05);试验组治疗后3,5,7 d p H值显著低于对照组(P<0.05)。结论谷氨酰胺能保护创伤性应激性胃肠道溃疡,且安全性高。
Objective To investigate the clinical effects of glutamine on traumatic stress gastrointestinal ulcers. Methods Ninety patients with traumatic stress gastrointestinal ulcer were divided into control group（ n = 45） and trail group（ n = 45）. Control group was treated with conventional western medicine,trail group was treated with glutamine 50 m L with 0. 9% Na Cl 250 m L intravenous drip. Both groups were treated for10 d. Clinical effect,Endoscopic mucosal lesions and p H after 3,5,7,9d treatment of the two groups were observed. Results The markedly effective and total effective of control group was 46. 67% and 82. 23%,significantly lower than those of trail group, which were 64. 44%,91. 12%（ P〈0. 05）. All patients had gastrointestinal mucosa lesions before treatment,the cases of no lesions after treatment were significantly increased of the two groups,trail group was higher than control group（ P〈0. 05）. The cases of mild,moderate,severe and extraordinarily severe lesions were significantly decreased of the two groups（ P〈0. 05）.The cases on moderate,and severe lesions in trail group were significant lower than control group（ P〈0. 05）. The p H value after 3,5,7,9 d treatment reduced than those before treatment; and after 3,5,7 d treatment,p H in trail group were significantly lower than that of control group（ P〈0. 05）. Conclusion Glutamine can protect traumatic stress gastrointestinal ulcers with high safety.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第23期2287-2289,共3页
The Chinese Journal of Clinical Pharmacology
基金
湖北省教育厅科学技术研究基金资助项目(D20141903)
