摘要
目的观察可吸收生物活性骨诱导材料修复兔股骨头无菌性坏死（ONFH）的效果。方法大白兔30只，臀肌注射醋酸氢化泼尼松，每次剂量为7．5mg／kg，每周2次，注射18周，制备ONFH模型。将大白兔随机分为实验组、对照组1和对照组2，每组10只。实验组于骨坏死处植入可吸收生物活性骨诱导材料人工骨；对照组1灌喂生脉成骨胶囊；对照组2于坏死处不加任何植入物。分别于植入材料之后的2、4、8周通过x射线及组织学观察评判骨坏死的发展及治愈情况。结果实验组骨坏死之塌陷处被修复，且松质骨和皮质骨再生，骨坏死基本愈合，植入的人工骨被逐渐降解吸收；对照组1也有部分骨组织血管骨髓修复再生，少许新骨生长，延缓了骨坏死的进程；而对照组2骨坏死塌陷处无任何骨组织再生，且进一步恶化。结论该可吸收生物活性骨诱导材料不仅能替代自体骨作为移植物，还具有抑制骨坏死发展的功能，有望用于临床治疗Ⅱ期及较早期股骨头坏死的替代疗法。
Objective To observe the outcome of an absorbable bioactive bone-inducing material for the treatment ofosteonecrosis of the femoral head （ONFH）. Methods Thirty rabbits were randomly, evenly divided into three groups, experience group with bioactive bone-inducing material planted into bone collapse, control group 1 with oral ShengMaiJiaoNang and control group 2 with no implantation in the bone necrosis. Results In experiment group, bone necrosis was halted and the collapse was repaired. Meanwhile, cancellous bone and cortical bone were regenerated, necrotic bone was basically healed, and bioactive bone-inducing material was gradually degraded and absorbed. In control group l, part of the bone marrow vascular was repaired and regenerated, and a little new bone grew, which delayed the process of necrosis. In control group 2, there was no bone tissue regeneration in the bone collapse and further deterioration was observed. Conclusions The bioactive bone-inducing material can not only replace autologous cancellous bone, but also halt the progress of osteonecrosis, which may become an alternative treatment for the stage II and early stage of ONFH.
出处
《国际生物医学工程杂志》
CAS
2015年第5期275-277,289,I0005,共5页
International Journal of Biomedical Engineering
基金
广东省中医药局科研基金资助项目（20121013）
关键词
可吸收生物活性
骨诱导
股骨头坏死
人工骨
Absorbable bioactivity
Bone induction
Osteonecrosis of the femoral head
Artificial bone
