摘要
目的探讨凝血、纤溶指标及血小板参数与喉癌临床分期及转移的关系。方法选取155例喉癌患者作为喉癌组,选择同期住院的80例喉部良性疾病患者作为对照组,检测2组入院次日晨起凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-dimer)以及血小板计数(Plt)、血小板压积(PCT)、血小板分布宽度(PDW)、血小板分布体积(MPV),分析喉癌组各指标水平与喉癌临床分期、有无转移、病理分化程度的关系。结果喉癌组Fib、D-dimer水平均明显高于对照组(P均<0.05)。喉癌组中Ⅲ期、Ⅳ期喉癌患者Fib、D-dimer、Plt水平均明显高于Ⅰ期、Ⅱ期患者(P均<0.05);发生转移患者APTT明显短于未转移患者,Fib、D-dimer、Plt水平明显高于未转移患者,差异均有统计学意义(P均<0.05);不同分化程度喉癌患者各指标水平比较差异均无统计学意义(P均>0.05)。结论喉癌患者血液呈高凝状态,且存在继发纤溶亢进,这种凝血与纤溶系统改变与喉癌的临床分期及有无转移有关,与喉癌病理分化程度无关。
Objective It is to investigate the relationship of blood coagulation,fibrinolysis and platelet parameter with clinical staging and metastasis in patients with laryngeal carcinoma. Methods The indexes of prothrombin time（ PT）,activated partial thromboplastin time（ APTT）,fibrinogen（ Fib）,D- dimer,platelet count（ Plt）,platelet hematocrit（ PCT）,platelet distribution width（ PDW） and mean platelet volune（ MPV） were detected in 155 patients with laryngeal carcinoma in laryngeal group and 80 patients with laryngeal benign disease in control group. The relationship of these indexes with clinical stage,metastasis and pathological differentiation degree were analyzed. Results The indexes of Fib and D- dimer in laryngeal carcinoma group were higher than those in control group（ all P 〈 0. 05）. The indexes of Fib,D- dimer and Plt in Ⅲ,Ⅳ stage were higher than those in Ⅰ,Ⅱ stage（ all P 〈 0. 05）. The index of APTT in patients with metastasis was shorter than that without,and Fib,D- dimer and Plt in patients with metastasis higher than those without,There were significant difference in all indexes. There was no significant difference in all indexes among the disparity differentiation of laryngeal carcinoma. Conclusion The patients with laryngeal carcinoma are in hypercoagulable and secondary hyperfibrinolysis,which concerned with laryngeal carcinoma clinical stage and metastasis.
出处
《现代中西医结合杂志》
CAS
2015年第36期4003-4005,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省卫生厅科研基金项目(20150462)
