摘要
目的探讨骨桥蛋白（OPN）和CD44拼接变异体6（CD44v6）在食管癌组织中的表达及其临床意义。方法采用免疫组化法检测58例食管癌及其相应癌旁正常组织标本OPN和CD44v6的表达情况，并分析其与食管癌患者临床病理特征间的关系。结果食管癌及其癌旁正常组织OPN表达阳性率分别为62．1％和6．9％，CD44v6表达阳性率分别为53．4％和8．6％，差异均有统计学意义（P〈0．05）。OPN和CD44v6的表达与肿瘤的浸润深度、淋巴结转移之间有关（P〈0．05），与肿瘤组织分化状态无关（P≥0．05）。OPN与CD44v6表达存在正相关关系（r=0．571，P〈0．01）。结论OPN和CD44v6在食管癌组织中高表达，并且在食管癌的浸润转移过程中具有一定的协同性。
Objective To investigate the levels of osteopontin （OPN） and CD44 splice variant 6 （ CD44v6 ） in esophageal cancer tissues and its clinical significance. Methods A total of 58 esophageal cancer specimens and adjacent normal tissues were collected. The levels of OPN and CD44v6 were detected by immunohistochemical staining, and their relationship with the pathological characteristics of esophageal cancer patients was analyzed. Results The positive rate of OPN was 62.1% and 6.9% in esophageal cancer specimens and adjacent normal tissues, respectively. The positive rate of CD44v6 was 53.4% and 8. 6% in esophageal cancer specimens and adjacent normal tissues, respectively. These data were significantly different from each other （P 〈 0.05）. The levels of OPN and CD44v6 were related with the depth of in- vasion and lymph node metastasis （P 〈 0.05 ）, rather than tumor differentiation. The amounts of OPN and CD44v6 were positively correlated with each other （r = 0. 571 ,P 〈 0.01 ）. Conclusion OPN and CD44v6 which are highly expressed in esophageal cancer tissues may play an important role in the invasiveness of esophageal cancer.
出处
《徐州医学院学报》
CAS
2015年第11期749-751,共3页
Acta Academiae Medicinae Xuzhou
