摘要
目的观察肿瘤相关巨噬细胞（TAMs）在甲状腺乳头状癌（PTC）的表达,探讨其在PTC侵袭转移中的作用。方法选取我院2010年10月~2013年10月期间经病理诊断为PTC患者80例,取病理标本,采用免疫组化法检测TAMs表达,对其临床特征进行分析。结果 TAMs在PTC中存在较高的表达（3~66/HP）,高密度TAMs组肿瘤组织直径（1.6±0.1）cm明显大于低密度TAMs组（1.0±0.1）cm（P〈0.01）。高密度TAMs组较低密度TAMs组肿瘤浸润深度更深,且有更多的淋巴结转移,Ⅲ期以上病例数也更多。结论 TAMs有促进PTC生长的作用,在PTC的侵袭和转移中发挥促进作用。
Objective To investigate the expression of tumor-associated macrophages（TAMs） in human papillary thyroid carcinoma（PTC） and the role of TAMs in invasion and metastasis of PTC. Methods Eighty patients who underwent surgeries after being diagnosed with PTC from Oct 2010 to Oct 2013 were included. Their paraffin-embedded tumor tissues were investigated using immunohistochemistry（IHC） and the clinical characteristics according to TAMs density was evaluated. Results The TAM densities varied from 3-66/HP, and tumors in the high density group were larger than those in the low density group [（1.6±0.1） cm vs（1.0±0.1） cm,P〈0.01]. Meanwhile, in the high density group, the tumor infiltration was deeper, and more lymph node metastasis and the number of post-phase Ⅲ cases were found. Conclusion TAMs has an effect on promoting the growth of the PTC, and plays an important role in invasion and metastasis of PTC.
出处
《中国现代医生》
2015年第34期11-13,17,共4页
China Modern Doctor
基金
浙江省自然科学基金资助项目(LQ12H16011)
关键词
肿瘤相关巨噬细胞
甲状腺乳头状癌
免疫组化
侵袭转移
Tumor-associated macrophages
Papillary thyroid carcinoma
Immunohistochemistry
Invasion and metastasis
