摘要
目的系统性红斑狼疮（SLE）是能够导致患者多脏器损害的自身免疫性疾病,其中肺动脉高压（PH）是严重威胁患者生命的并发症之一。分析SLE患者合并PH的临床特点,讨论PH在SLE患者中发生的影响因素。方法我院就诊的SLE患者,初诊并未经过治疗的患者。回顾性分析100例SLE合并PH患者,并与同期100例无PH的SLE患者进行比较分析。结果 SLE患者合并PH的100例患者年龄14-77岁,平均（33.1±12.3）岁;其中男性8例,女性92例。雷诺现象、间质性肺炎、心包积液和抗心磷脂抗体阳性等因素与SLE患者发生PH呈正相关（P〈0.05）。结论 SLE是自身免疫性疾病合并PH中的较常见疾病,对于出现雷诺现象、间质性肺炎、心包积液和抗心磷脂抗体阳性的SLE患者应警惕发生PH的风险。
Objective Systemic lupus erythematosus（SLE）is an autoimmune disease that has various manifestations and involves virtually all organs. Pulmonary hypertension（PH）is a serious life-threatening complication of SLE.The study is to investigate the clinical manifestations,and the affecting factors of PH in patients with SLE.Methods One hundred SLE patients identified to have concomitant PH by echocardiography were enrolled.The clinical data of 100 patients were analyzed retrospectively.Clinical features,and laboratory data were compared between SLE patients with PH and without PH.Results 100 SLE patients with concomitant PH included 8men and92 women,aged from 14 to 77years,mean age（33.1±12.3）years.Positive correlations were identified between the occurrence of PH and the Raynaud phenomenon,interstitial pneumonia,pericardial effusion,and anti-phospholipid antibody positive（P〈0.05）.Conclusion PH is not a rare concomitant disease in SLE patients.The presence of Raynaud phenomenon,interstitial pneumonia,pericardial effusion and anti-phospholipid antibody positivity all suggest the probability of PH in SLE patients.
出处
《临床荟萃》
CAS
2015年第12期1402-1405,共4页
Clinical Focus
关键词
高血压
肺性
红斑狼疮
系统性
雷诺现象
肺疾病
间质性
心包积液
抗心磷脂抗体
hypertension
pulmonary
lupus erythematosus
systemic
Raynaud phenomenon
pneumonia
interstitial
pericardial effusion
anti-phospholipid antibody
