期刊文献+

细菌耐药性研究进展 被引量:42

Research Progress on Bacterial Resistance
下载PDF
导出
摘要 细菌抗生素类药物耐药性的产生是临床治疗感染性疾病的一大难题,已受到人们的广泛关注。细菌主要通过产生灭活酶或钝化酶获得耐药性,除此之外还有细胞壁的渗透障碍、外排泵的泵出作用、靶位改变等多种机制,这些机制相互作用共同决定细菌的耐药水平。随着新型抗生素的临床应用,新的耐药机制随之出现,耐药菌也越来越广泛。细菌耐药机制的研究对耐药菌的控制和新药开发具有指导性意义。文章从耐药性的起源、产生机理、耐药特性及耐药性的检测方法4个方面进行了阐述。 Antibiotic resistance of bacteria is a major problem in the clinical treatment of infectious diseases,and it has received the extensive attention.Bacteria producing inactivated enzyme or passivated enzyme is a mainly way to acquire resistance.Besides,the mechanisms of cell wall permeability barrier,efflux pump and target changes are existed,these mechanisms interact to the level of the bacterial antibiotic resistance.With the clinical application of new antibiotic,the new resistant mechanisms emerge and the antibiotic-resistant bacteria are widespread.The study of bacterial resistance mechanisms has instructional meaning for antibiotic-resistant bacteria control and new drug development.We elaborated the bacterial resistance from the origin of the resistance,mechanisms,characteristics and test method in this article.
出处 《中国畜牧兽医》 CAS 北大核心 2015年第12期3371-3376,共6页 China Animal Husbandry & Veterinary Medicine
基金 国家自然科学基金(31272603 31101836)
关键词 细菌 抗生素 耐药性 耐药机制 bacteria antibiotics resistance resistance mechanism
  • 相关文献

参考文献40

  • 1赵明秋,沈海燕,潘文,王佳莹,李银光,常艳.细菌耐药性产生的原因、机制及防治措施[J].中国畜牧兽医,2011,38(5):177-181. 被引量:46
  • 2Casali N, Nikolayevskyy V, Balabanova Y, et al.Microevolution of extensively drug-resistant tubercu- losis in Russia[J]. Genome Res, 2012,22 (4) . 735-745.
  • 3Gandhi N R, Nunn P, Dheda K, et al. Multidrug-re- sistant and extensively drug-resistant tuberculosis:A threat 200 to global control of tubereulosis[]~. Lan- cet, 2010,375 (9728) : 1830-1843.
  • 4Martinez JL,gaciuero F. Emergence and spread of an- tibiotic resistance: Setting a parameter space[J]. Ups J .IVied Sci, 2014,119 (2) ~ 68-77.
  • 5Riesenfeld C S,Goodman R M, Handelsman J. Uncul- tured soil bacteria are a reservoir of new antibiotic re- sistance genes [J]. Environ Microbiol, 2004, 6 (9): 981-989.
  • 6Martinez J L,Sanchez M B,Martinez-Solano L,et al. Functional role o{ bacterial multidrug efflux pumps in microbial natural ecosystems[J]. FEMS Microbiol Rev ,2009,33(2) :430-449.
  • 7刘五高,丁友法,刘爱霞,黄黎俐,金晶,王伟.质粒介导的耐药基因水平传播研究进展[J].中国卫生检验杂志,2015,25(8):1288-1292. 被引量:10
  • 8Hudson L O, Murphy C R, Spratt B G, et al. Differ- ences in methicillin-resistant Staphylococcus aureus strains isolated from pediatric and adult patients from hospitals in a large county in California [J]. J Clin Microbiol ,2012,50(3) :573-579.
  • 9Pfeifer Y,Cullik A, Witte W. Resistance to cephalo- sporins and carbapenems in Gram-negative bacterial pathogens~-J~. Int J Med Microbiol, 2010, 300 (6) : 371-379.
  • 10Medeiros A A. Evolution and dissemination of l?-lacta- mases accelerated by generations of 13-1actam antibiot- ics[J]. Clin Infect Dis,1997,24(1) ~19-45.

二级参考文献206

共引文献299

同被引文献388

引证文献42

二级引证文献245

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部