摘要
目的:探讨男性少、弱、无精症以及胎停育、畸胎、反复性流产等生殖异常患者的细胞遗传学原因。方法:针对我院720例生殖异常患者,做常规技术的外周血淋巴细胞培养,采用G显带法进行染色体核型分析。结果:720例生殖异常患者中,检出异常核型69例。其中,多态性核型为49例,包括9qh+3例,inv(9)1例,Ds+/Gs+10例,Yqh+35例。Turner综合征3例,Klinefelter综合征12例,平衡易位等5例。结论:染色体核型异常与生殖异常存在密切的关系,异常核型会导致男性少、弱、无精症以及畸胎孕产史和妊娠的反复失败,且染色体多态性与生殖异常关系尤为密切,建议临床应给予足够重视。
Objective：To investigate the cytogenetic reason of patients under going reproductive abnormalities such as azoospermia,malformation fetus,recurrent spontaneous abortion.Methods：For examination of 720 patients with reproductive abnormalities,as a conventional technique of peripheral blood lymphocyte culture,by using G banding karyotype analysis.Results：Of 720 patients with abnormal reproductive,69 cases of abnormal karyotypes was detected in this study.Among them,there were 49 cases of the polymorphism karyotype,including 3cases in 9qh＋,1case in inv（9）,10 cases in Ds＋/Gs＋,35 cases in Yqh＋,3cases in Turner syndrome,12 cases in Klinefelter syndrome,5cases in balanced translocation.Conclusion：Abnormal chromosome karyotype and there is a close relationship between reproductive abnormalities and abnormal karyotype,leading azoospermia,malformation fetus,recurrent spontaneous abortion and so on.Further more,the relationship is closer between chromosome polymorphism and reproductive abnormalities,therefore,much more attention should be given to this point in clinical.
出处
《医学理论与实践》
2015年第22期3040-3042,共3页
The Journal of Medical Theory and Practice
关键词
染色体核型分析
生殖异常
染色体多态性
Karyotype analysis
Reproductive abnormalities
Chromosome polymorphism
