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培美曲塞或吉西他滨联合奥沙利铂治疗复发晚期卵巢上皮癌的疗效观察 被引量:1

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摘要 目的 观察培美曲塞或吉西他滨联合奥沙利铂治疗复发晚期卵巢上皮癌的疗效及毒副反应。方法选取我院2011年3月~2014年10月收治的复发晚期卵巢上皮性癌患者49例作为研究对象,将其随机分为培美曲塞联合顺铂(PP)组25例与吉西他滨联合顺铂(GP)组24例。PP组患者给予培美曲塞联合奥沙利铂进行治疗;GP组患者给予吉西他滨联合奥沙利铂进行治疗。两组均以3周为1个周期,每2个周期后评价两组患者的疗效及不良反应。结果 PP组和GP组总有效率分别为44%,37.5%,临床受益率分别为72%,70.8%,差异无统计学意义(P〉0.05);但在不良反应方面,如中性粒细胞减少和血小板减少,PP组明显低于GP组,差异有统计学意义(P〈0.05)。结论 培美曲塞联合奥沙利铂二线治疗复发晚期卵巢癌有较高的肿瘤控制率,毒副反应小,耐受性好,同时可提高患者的生活质量,值得临床推广与应用。
作者 周艳
机构地区 唐河县人民医院
出处 《实用妇科内分泌电子杂志》 2015年第9期168-168,170,共2页 Electronic Journal of Practical Gynecological Endocrinology
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  • 1周兆飞,陆建伟,尹必俭,刘德林,冯继锋,朱梁军,潘良熹.奥沙利铂联合5-氟脲嘧啶、甲酰四氢叶酸时辰治疗晚期胃肠道癌的临床研究[J].实用临床医药杂志,2007,11(2):16-18. 被引量:9
  • 2Calvert H.An overview of folate metabolism:Features relevant to the action and toxicities of antifolate anticancer agents[J].Semin Oncol,1999,26(2Suppl6):3.
  • 3Rollins KD,Lindley C.Pemetrexed:a multitargeted antifolate[J].Clin Ther,2005,27(9):1343-1382.
  • 4Taylor P,Castagneto B,Dark G,et al.Single-agent pemetrexed for chemona? ve and pretreated patients with malignant pleural mesothelioma:results of an International Expanded Access Program[J].Thorac Oncol,2008,3(7):764-771.
  • 5Athanasios X,Torsten TB,Torsten GB,et al.Gemcitabine combined with oxaliplatin in pretreated patients with malignant pleural mesothelioma:an observational study[J].Occup Med Toxicol,2008,3:34.
  • 6Hanna N,Shepherd FA,Fossella FV,et al.Randomized phase Ⅲ trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy[J].J Clin Oncol,2004,22(9):1589-1597.
  • 7Heist RS,Fidias P,Huberman M,et al.A phase II study of oxaliplatin,pemetrexed,and bevacizumab in previously treated advanced non-small cell lung cancer[J].J Thorac Oncol,2008,3(10):1153-1158.
  • 8Sun JM,Lee KW,Kim Jh,et al.Efficacy and toxicity of pemetrexed as a third-line treatment for non-small cell lung cancer[J].Jpn J Clin Oncol,2009,39(1):27-32.
  • 9Llombart-Cussac A,Theodoulou M,Rowland K,et al.Pemetrexed in patients with locally advanced or metastatic breast cancer who had received previous anthracycline and taxane treatment:phase Ⅱ study[J].Clin Brest Cancer,2006,7(5):380-385.
  • 10Matulonis UA,Horowitz NS,Campos SM,et al.Phase Ⅱ study of carboplatin and pemetrexed for the treatment of platinum-sensitive recurrent ovarian cancer[J].J Clin Oncol,2008,26(35):5761-5766.

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