摘要
目的分析肿瘤标志物(血清癌胚抗原(CEA)、糖蛋白抗原19-9、724和242(CA19-9、CA724、CA242))联检在胃癌早期诊断的应用价值。方法在我院2014年6月至2015年6月,选取60例确诊为胃癌的患者作为实验组,同期58例诊断为慢性萎缩性胃炎伴重度不典型增生作为CAGD组和61例诊断为胃部黏膜正常或浅表型胃炎患者作为对照组,分析患者血清CEA、CA242、CA19-9、CA724的水平。结果在实验组,低分化型患者血清CA242、CA19-9、CA724的阳性检出率显著性高于中高分化型患者(P<0.05);Ⅲ期、Ⅳ期患者血清CEA、CA242、CA19-9、CA724的阳性率明显高于Ⅰ、Ⅱ期患者(P<0.05);发生肝脏转移的胃癌患者血清CEA、CA242、CA19-9、CA724的阳性率明显高于未发生肝转移的患者(P<0.05)。实验组血清CEA、CA242、CA19-9、CA724水平明显高于CAGD组和对照组(P<0.05),CAGD组血清CEA、CA242、CA19-9、CA724水平高于对照组(P<0.05)。单项检测胃癌敏感性最高的是CA724(58.33%),单项检测特异性最高的是CA19-9(95.00%),而CA242+CA19-9+CA125联合检测的敏感性和特异性最高,分别为76.67%、98.33%,高于任何单项检测。结论肿瘤标志物联检可提高检测的灵敏性和特异性,可作为早期诊断胃癌、指导治疗、病情监测的有力工具。
Objective To analyze the application value of tumor markers（ carcinoembryonic antigen（ CEA）,glycoprotein antigens 19- 9,724,242（ CA19- 9,CA724,CA242）） combined detection in the early diagnosis of gastric cancer. Methods From June 2014 to June 2015,60 patients diagnosed as gastric cancer were involved into the experiment group,58 patients diagnosed as chronic atrophic gastritis combined with severe atypical hyperplasia were involved into the CAGD group and 61 patients diagnosed with normal gastric mucosa or superficial gastritis were involved into the control group at the same period. The serum levels of CEA,CA242,CA19- 9 and CA724 were analyzed. Results The serum CA242,CA19- 9 and CA724 positive rate of patients diagnosed as low tumor differentiation in the experiment group were obviously higher than those of medium or high tumor differentiation（ P〈0. 05）. The serum CEA,CA242,CA19- 9 and CA724 positive rate of patients at clinical Ⅲ or Ⅳ stage were significantly higher than those of patients at clinical Ⅰor Ⅱstage（ P〈0. 05）. The serum CEA,CA242,CA19- 9 and CA724 positive rate of patients with liver metastasis were significantly higher than those of patients without liver metastasis（ P〈0. 05）. The serum levels of CEA,CA242,CA19- 9 and CA724 in the experiment group were significantly higher than those of the CAGD group and the control group respectively（ P〈0. 05）. The serum levels of CEA,CA242,CA19- 9 and CA724 in the CAGD group were significantly higher than those of the control group（ P〈0. 05）. The highest sensitivity and specificity of single test was CA724（ 58. 33%） and CA19- 9（ 95. 00%）,but the sensitivity and specificity of combined detection of serum CA242,CA19- 9 and CA125 was respectively 76. 67% and 98. 33%,higher than any single detection.Conclusions The tumor markers combined detection can improve the sensitivity and specificity of detection and could be a powerful tool for early diagnosis of gastric cancer,guiding treatment and surveillance of disease.
出处
《齐齐哈尔医学院学报》
2015年第33期4995-4997,共3页
Journal of Qiqihar Medical University
关键词
肿瘤标志物
联检
胃癌
早期诊断
Tumor maker
Combined detection
Gastric cancer
Early diagnosis
