摘要
目的 :探讨原发腹膜后黏液囊腺癌(primary retroperitoneal mucinous cystadenocarcinoma,PRMC)患者的临床和病理组织学特征。方法:应用苏木精-伊红(HE)及免疫组织化学染色观察2例PRMC患者肿瘤的组织病理学特征,并结合相关文献进行分析。结果:2例患者经盆腔CT检查发现腹膜后巨大囊性占位。手术标本的病理检查显示,肿块的组织学形态为纤维囊壁组织衬覆增生的黏液柱状上皮,伴细胞内和(或)细胞外黏液,乳头状和(或)筛状结构,细胞异型性明显,伴间质毁损性浸润;肿瘤细胞CK7、CK20、β-catenin阳性,p53不同程度阳性,PR、ER和糖类抗原125阴性。结论:PRMC是临床罕见的肿瘤,检测肿瘤组织中β-catenin和p53的表达可能有助于鉴别。手术完整切除肿瘤后,患者的预后较好。
Objective： To study the clinical and morphologic features of primary retroperitoneal mucinous cystadeno-carcinoma（PRMC）. Methods： Pathologic characteristics and immunophenotype of 2 cases of PRMC were analyzed by HE and immunohistochemical staining, and related literatures were reviewed. Results： Two female patients with huge retroperitoneal mass in pelvis detected by computed tomography CT） were enrolled. Pathological examination revealed micropapillary and/or cribriform inner lining covering hyperplastic mucus columnar epithelial cells. Tumor cells showed dis-tinct atypia with intracytoplasmic and/or extracellular mucin, and infiltration was seen in the stroma of cyst wall. CK7,CK20 and β-catenin were expressed in neoplastic cells and p53 was expressed in different degree. PR, ER, CA125 were immunohistochemically negative. Conclusions： PRMC is a rare tumor. Detection of β-catenin and p53 may be helpful for differential diagnosis. Patient has better prognosis after complete excision of the tumor.
出处
《诊断学理论与实践》
2015年第4期348-352,共5页
Journal of Diagnostics Concepts & Practice
关键词
腹膜后肿瘤
黏液性囊腺癌
müller型肿瘤
病理
Retroperitoneal tumor
Mucinous cystadenocarcinoma
Tumor of müllerian type
Pathology
