摘要
目的观察丙泊酚联合咪达唑仑在先天性心脏病患儿术后镇痛镇静的临床疗效。方法 58名先天性心脏病患儿分为对照组29例和试验组29例。试验组予以咪达唑仑0.2μg·kg^(-1)·min^(-1),连续给药至拔管后1 h,丙泊酚10μg·kg^(-1)·min^(-1)连续给药至拔管后1 h;对照组术后使用咪达唑仑1μg·kg^(-1)·min^(-1),连续给药至拔管后1 h。比较2组患儿术后的拔管时间、在重症监护室(ICU)停留的时间以及苏醒后谵妄的发生率。结果试验组患儿的拔管时间为(30.31±3.52)h,显著低于对照组的(38.22±4.41)h(P<0.05)。试验组患儿在ICU的停留时间为(43.22±5.11)h,显著低于对照组的(51.52±5.83)h(P<0.05)。对照组5例(17.2%)患儿在苏醒后出现谵妄,试验组4例(13.8%),差异无统计学意义(P>0.05)。结论丙泊酚联合咪达唑仑可以减少先天性心脏病患儿术后的拔管时间和在ICU停留时间。
Objective To observe the clinical efficacy of propofol combined with midazolam for pediatric patients with congenital heart disease requiring postoperative sedation.Methods Fifty- eight patients with congenital heart disease were divided into control group（n = 29） and treatment group（n = 29）.Patients in control group received midazolam 1μg·kg^-1·min^-1 consecutively until 1 hour post extubation,patients in treatment group received midazolam 0.2 μg·kg^-1·min^-1 consecutively plus propofol 10 μg·kg^-1·min^-1 consecutively until 1 hour post extubation.The extubation time,intensive care unit（ICU） stay time and delirium incidence were evaluated.Results The extubation time（38.22±4.41） h and ICU stay time（51.52±5.83） h in control group were longer than those in treatment group,which were（30.31±3.52）,（43.22±5.11） h（P〈0.05）.The incidence of delirium in control group was 5 cases（17.2%）,and 4 cases in treatment group（13.8%,P〉0.05）.Conclusion For pediatric patients with congenital heart disease requiring postoperative sedation,application of propofol combined with midazolam can lower the extubation time and ICU stay time.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第24期2378-2380,共3页
The Chinese Journal of Clinical Pharmacology
基金
2013年省医药卫生平台骨干人才计划基金资助项目(2013RCB012)
关键词
丙泊酚
咪达唑仑
儿童
先天性心脏病
镇静
镇痛
propofol
midazolam
child
congenital heart disease
sedation
analgesia
