摘要
目的 分析血清25羟维生素D[25（OH）D]与颈动脉粥样硬化的相关性。方法 选取2014年-2015年南京鼓楼医院体检者100例,男性76例,女性24例,年龄39-81岁。将患者分为4组,25（OH）D〉30 ng/ml为正常组（9例）,20 ng/ml〈25（OH）D≤30 ng/ml为轻度缺少组（38例）,15 ng/ml〈25（OH）D≤20 ng/ml为缺少组（35例）,25（OH）D≤15 ng/ml为缺乏组（18例）。酶联免疫吸附试验双抗体夹心法检测血清25（OH）D,应用荷兰PHILIPS公司四维彩超IU-Elite测量双侧颈总动脉内膜中层厚度,测量三个心动周期。结果 正常组比较,轻度缺少组、缺少组和缺乏组,颈动脉内膜中层厚度均增加,数值为[（0.58±0.15）mm vs.（0.75±0.22）mm]、[（0.58±0.15）mm vs.（0.92±0.24）mm]、[（0.58±0.15）mm vs.（1.13±0.30）mm],差异有统计学意义（P均〈0.05）。25（OH）D为颈动脉粥样硬化的独立保护因素（OR=0.947,95%CI：0.907-0.990）,年龄（OR=1.096,95%CI：1.009-1.191）和尿酸（OR=1.112,95%CI：1.007-1.201）为颈动脉粥样硬化的独立危险因素。Pearson相关分析,颈动脉内膜中层厚度与25（OH）D呈负相关（r=-0.49,P〈0.05）。结论 血清25（OH）D水平与颈动脉内膜中层厚度呈负相关,是颈动脉粥样硬化的独立保护因素。
Objective To analyze the correlation between serum 25 hydroxy vitamin D [25（OH）D] and carotid atherosclerosis. Methods The patients（n=100, male 76, female 24 and aged from 39 to 81） were chosen from 2014 to 2015, and then divided into group A（25（OH）D30 ng/m L, n=9）, group B（20 ng/m L25（OH）D≤30 ng/m L, n=38）, group C（15 ng/m L25（OH）D≤20 ng/m L, n=35） and group D（25（OH）D≤15 ng/m L, n=18）. The level of serum 25（OH）D was detected by using double antibody sandwich ELISA, and carotid artery intima-media thickness（CAIMT） was detected for 3 cardiac cycles. Results Compared with group A, CA-IMT increased in group B, group C and group D [（0.58±0.15） mm vs.（0.75±0.22） mm,（0.58±0.15） mm vs.（0.92±0.24） mm,（0.58±0.15） mm vs.（1.13±0.30） mm, all P〈0.05]. 25（OH）D was the independent protective factor of carotid atherosclerosis（OR=0.947, 95%CI： 0.907-0.990）, and age（OR=1.096, 95%CI： 1.009-1.191） and uric acid（OR=1.112, 95%CI： 1.007-1.201） were the independent risk factors for carotid atherosclerosis. Pearson correlation analysis showed that CA-IMT was negative related to 25（OH）D（r=-0.49, P〈0.05）. Conclusion The level of serum 25（OH）D is negatively related to CA-IMT, and is the independent protective factor of carotid atherosclerosis.
出处
《中国循证心血管医学杂志》
2015年第6期801-803,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
