摘要
目的复制急性心力衰竭模型,基于α、β肾上腺素能受体探讨附子抗急性心力衰竭药效作用及相关机制。方法采用iv大剂量戊巴比妥钠的方法复制大鼠急性心衰模型,分别设附子高、低剂量组及附子与α、β肾上腺素受体阻断药合用组,动态监测模型大鼠左室收缩压(LVSP)、心率(HR)、左室内压上升/下降最大速率(±dp/dtmax)等血流动力学相关指标,评价附子对急性心衰大鼠心功能的影响。结果与模型组相比,附子具有显著升高血压、加快HR及加强心肌收缩力的作用(P<0.05、0.01),且表现出一定程度的量-效、时-效关系。与附子给药组相比,α、β受体阻断药均能显著拮抗附子升压作用,β受体阻断药能显著拮抗附子加快HR作用(P<0.05、0.01)。结论附子对急性心衰大鼠具有明显的强心作用,其部分机制与激动α、β肾上腺素能受体有关。
Objective To observe the effects of Aconiti Lateralis and Radix Preparata（ALRP） on hemodynamic indexes of rats with acute heart failure（AHF） and to study its possible mechanism of α and β adrenergic receptor-related action. Methods The AHF model in Wistar rats was induced by injecting large doses of pentobarbital. Rats were received high and low doses of ALRP as well as α and β adrenergic receptor blockers to observe the effect on hemodynamics（LVSP, HR, and ±dp/dtmax） in rats. Results ALRP could significantly increase blood pressure, heart rate, and myocardial contractility compared with the control group（P 〈 0.05, 0.01）, and it also exhibited a certain degree of volume-efficiency and time-effect relationship. The pressor effect of ALRP could be significantly reduced by α and β adrenergic receptor blockers. Moreover the increasing heart rate effect of ALRP could be significantly reduced by β adrenergic receptor blocker（P 〈 0.05, 0.01）. Conclusion ALRP can significantly enhance the cardiac function in rats with AHF and the possible mechanism of this effect is associated with α and β adrenergic receptors.
出处
《中草药》
CAS
CSCD
北大核心
2015年第21期3223-3234,共12页
Chinese Traditional and Herbal Drugs
基金
国家重点基础研究发展规划("973"计划)项目(2011CB505300
2011CB505302)
关键词
附子
急性心力衰竭
肾上腺素能受体
强心作用
血流动力学
Aconiti Lateralis Radix Preparata
acute heart failure
adrenergic receptor
cardiac effects
hemodynamics
