摘要
通过系统的植物化学分离分析方法,研究骆驼蹄瓣中的萜类化学成分。运用硅胶柱色谱、凝胶柱色谱（Sephadex LH-20）对乙酸乙酯部位进行分离纯化,然后通过现代波谱学鉴定方法（1H-NMR,13C-NMR,MS）和结合文献数据分析确定化合物的结构。从乙酸乙酯部位分离并鉴定13个化合物,结构分别为1-羟基茅苍术醇（1）,茅苍术醇（2）,白术内酰胺（3）,β-桉叶醇（4）,5α-氢过氧基-β-桉叶醇（5）,12-羟基-2-酮基-1-瓦伦烯（6）,毛脉五味子醇A（7）,（6S,7E）-6-羟基-4,7-大柱烯-3,9-二酮（8）,3-羟基-5α,6α-环氧-β-紫罗兰酮（9）,（3S,5R,6S,7E）-3,5,6-三羟基-7-大柱烯-9-酮（10）,（6R,7E,9R）-9-羟基-4,7-大柱烯-3-酮（11）,（S）-3-羟基-β-紫罗兰酮（12）,布卢门醇A（13）。其中化合物1~7为倍半萜,8~13为大柱烷类降倍半萜,以上化合物均为首次从骆驼蹄瓣中分离得到,化合物1为新的天然产物。
This study was to investigate the chemical constituents of the aerial part of Zygophyllum fabago,by phytochemical methods. The compounds were isolated by silica gel and Sephadex LH-20 column chromatographies from the Et OAc extract. Their structures were characterized by various spectroscopic data（1H-NMR,13C-NMR,MS） and comparison with the literature. As a result,thirteen compounds were isolated and their structures were identified as 1-hydroxyhinesol（ 1）,hinesol（ 2）,atractylenolactam（ 3）,β-eudesmol（ 4）,5α-hydroperoxy-β-eudesmol（ 5）,12-hydroxy-valenc-1（ 10）-en-2-one（ 6）,pubinernoid A（ 7）,（ 6S,7E）-6-hydroxy-4,7-megastigmadien-3,9-dione（ 8）,3-hydroxy-5α,6α-epoxy-β-ionone（ 9）,（ 3S,5R,6S,7E）-3,5,6-trihydroxy-7-megastigmen-9-one（ 10）,（ 6R,7E,9R）-9-hydroxy-4,7-megastigmadien-3-one（ 11）,（ S）-3-hydroxy-β-ionone（ 12）,and blumenol A（ 13）. Compounds 1-7 were sesquiterpenoids and 8-13 were megastigmane type norsesquiterpenoids. All the compounds were obtained from Z. fabago for the first time,and compound 1 was a new natural product.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第23期4634-4638,共5页
China Journal of Chinese Materia Medica
基金
昆明学院校级课题(XJL14024)
关键词
骆驼蹄瓣
倍半萜
化学成分
Zygophyllum fabago
sesquiterpenes
chemical constituents
