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DNA甲基化与口腔鳞状细胞癌的相关性研究进展 被引量：5

Research progress on the association between DNA methylation and oral squamous cell carcinoma
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摘要 DNA甲基化紊乱会增加人类罹患肿瘤的危险性。在口腔鳞状细胞癌(OSCC)研究中,以癌相关基因高甲基化研究相对较多,以甲基化特异性聚合酶链反应检测为主,多集中于健康黏膜-癌旁健康组织和肿瘤组织,以肿瘤早期诊断和恶性转化判定为目的。OSCC全基因组甲基化水平研究多采用高通量检测技术。获得癌前病变与健康黏膜、鳞状细胞癌与癌前病变、鳞状细胞癌与健康黏膜的DNA甲基化数据及DNA甲基化差异表达情况,可为下一步候选基因DNA甲基化研究奠定基础。 DNA rnethylation disorders may increase the risk of human cancer. Research on DNA hypermethylation of cancer-related genes in oral squamous cells is relatively extensive; such research is based on detection via methylation- specific polymerase chain reaction and centered on healthy mucosa-associated tissues, as well as tumor tissue adjacent to carcinoma, to determine early diagnosis and malignant transformation. Research on oral squamous cell carcinoma generally focuses on the level of genomic DNA methylation using high-throughput detection technology. The expression levels of DNA methylation were obtained from healthy mucosa and precancerous lesions on squamous cell carcinoma. The results of this work provide a solid foundation for subsequent studies on the methylation of candidate genes.
作者 涂敏松 李逸松 代晓明
机构地区 昆明医科大学附属口腔医院口腔颌面外科 昆明医科大学第一附属医院整形外科
出处 《国际口腔医学杂志》 CAS 北大核心 2016年第1期79-84,共6页 International Journal of Stomatology
基金 昆明医科大学应用基础研究联合专项基金(H1310177B)~~
关键词 DNA甲基化 表观遗传 口腔鳞状细胞癌 癌相关基因 DNA methylation epigenetic oral squamous cell carcinoma cancer-related gene
分类号 R739.85 [医药卫生—肿瘤]
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参考文献32

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二级参考文献16

  • 1龚飞飞,叶茂昌.P14ARF及其与口腔癌的关系[J].口腔医学研究,2007,23(1):103-105. 被引量：1
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国际口腔医学杂志
2016年 第1期

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