摘要
目的考察阿司匹林和华法林对心房颤动（AF）患者抗栓治疗的疗效。方法选取2013年7月～2014年10月进入我院的患者100名,根据双盲随机化的原则,将患者分为阿司匹林对照组和华法林治疗组。通过观察患者治疗前后的症状变化,比较两者用药的治疗效果;测定两组患者治疗前后的Fbg、D-dimer及HCT水平,观察对照组和治疗组患者的凝血活性变化;采用放射免疫法检测血浆中6-keto-PGF1 a和TXB2的含量并计算比值,考察阿司匹林和华法林对前列腺环素和血栓素平衡的影响;采用放射免疫法,考察AF患者治疗前后血浆中BNP的含量变化;通过测定血浆中CRP的水平及TNF-α和L-6的水平,比较治疗前后对照组和治疗组患者的炎症反应。结果经规范化治疗后,对照组和治疗组患者的血栓前状态均得到较大改善。临床疗效判定结果表明,阿司匹林和华法林均具有良好的抗栓效果,华法林疗效优于阿司匹林。与治疗前相比,抗栓治疗后AF患者血浆中与凝血活性相关的Fbg、D-dimer及HCT水平明显下降（P〈0.05）,前列腺环素和血栓素恢复平衡,与炎症相关的BNP、CRP水平及TNF-α和L-6水平均明显下降（P〈0.05）。结论阿司匹林和华法林均可用于AF患者的血栓防治,华法林的治疗效果优于阿司匹林。
Objective To observe the effect of warfarin compared to aspirin in patients with atrial fibrillation. Methods A randomized approach was study. Patients with atrial fibrillation were treated with aspirin（ 50 cases） and warfarin（ 50 cases）,respectively. The changes in syndrome were observed. The levels of Fbg,D-dimer,HCT,6-keto-PGF1 a and TXB2 in plasma were measured. Also,BNP,TNF-α and L-6 levels were measured. Results The syndromes on patients with atrial fibrillation were improved obviously. The plasma Fbg,D-dimer,HCT,BNP and TNF-α levels in patients treated with aspirin or warfarin were significant difference（ P〈0. 05） compared to the levels before treatment. Prostaglandins and thromboxane restore balance. Conclusion From the results of our study,it is evident that patients treated with warfarin are better than patients treated with aspirin.
出处
《血栓与止血学》
2015年第5期270-273,共4页
Chinese Journal of Thrombosis and Hemostasis
关键词
阿司匹林
华法林
血栓
Aspirin
Warfarin
Atrial fibrillation
